Results 11 to 20 of about 83,277 (241)

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain [PDF]

Molecular Brain, 2018
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain.
Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka   +6 more
doaj   +2 more sources

Scambio, a novel guanine nucleotide exchange factor for Rho

Molecular Cancer, 2004
Background Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis.
Groffen John, Senadheera Dinithi, Haataja Leena, Hemmeryckx Bianca, Curtis Christina, Heisterkamp Nora   +5 more
doaj   +3 more sources

Editorial: Guanine nucleotide exchange factors as determinants of cell fate and development [PDF]

Frontiers in Cell and Developmental Biology
Vegesna Radha, Katsuhiko Tabuchi, Katsuhiko Tabuchi, Jacek Z. Kubiak, Jacek Z. Kubiak   +4 more
doaj   +2 more sources

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

Genetic analysis of GEFs and GDIs in rice reveals the roles of OsGEF5, OsGDI1, and OsGEF3 in the regulation of grain size and plant height

Crop Journal, 2023
Guanine nucleotide exchange factors (GEFs) and guanine nucleotide-dissociation inhibitors (GDIs) regulate small GTPase proteins, which function as molecular switches in various signaling pathways, but their identification and functions in plants are not ...
Munsif Ali Shad, Yixian Wang, Hui Zhang, Shanshan Zhai, Abdullah Shalmani, Yibo Li   +5 more
doaj   +1 more source

Role of ARHGEF3 as a GEF and mTORC2 Regulator

Frontiers in Cell and Developmental Biology, 2022
Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq, Sana Abdul Khaliq, Zobia Umair, Mee-Sup Yoon, Mee-Sup Yoon, Mee-Sup Yoon   +5 more
doaj   +1 more source

Targeting Rac and Cdc42 GEFs in Metastatic Cancer

Frontiers in Cell and Developmental Biology, 2020
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado, Julia Isabel Medina, Luis Velazquez, Suranganie Dharmawardhane   +3 more
doaj   +1 more source

P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments [PDF]

, 2013
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers.
A Eriksson, A Eva, A Hall, A Malliri, AJ Ridley, AM Woodward, Andrew D. Campbell, Antonio Facchiano, Bradford W. Ozanne, CR Lindsay, CR Lindsay, D Hanahan, D Hanahan, F Michiels, FG Haj, FK Johansson, FK Johansson, FN van Leeuwen, G Bergers, H Gerhardt, HC Welch, Heidi C. Welch, J Qin, JC Montero, Jim C. Norman, JM Ebos, K Hill, K Uhlenbrock, KL Rossman, LA Scott, Lynn C. McGarry, M Paez-Ribes, MA Barber, MJ Hart, MS Sosa, OD Weiner, PT Hawkins, R Heuchel, RA Seifert, RF Hennigan, RJ Petrie, S Katzav, Samuel Lawn, U Rodeck, X Xian   +44 more
core   +11 more sources

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Frontiers in Molecular Biosciences, 2021
RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka, Yoshihisa Hirota, Yoshihisa Hirota, Doshun Ito, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Toshiya Senda, Toshiya Senda, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki   +18 more
doaj   +1 more source

Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma

Molecular & Cellular Oncology, 2021
In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells.
Mariana Cooke
doaj   +1 more source