Results 11 to 20 of about 9,354,840 (235)

Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP

Bio-Protocol, 2018
GTPases are molecular switches that cycle between the inactive GDP-bound state and the active GTP-bound state. GTPases exchange nucleotides either by its intrinsic nucleotide exchange or by interaction with guanine nucleotide exchange factors (GEFs ...
Tomoharu Kanie, Peter Jackson
doaj   +2 more sources

Scambio, a novel guanine nucleotide exchange factor for Rho

Molecular Cancer, 2004
Background Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis.
Groffen John, Senadheera Dinithi, Haataja Leena, Hemmeryckx Bianca, Curtis Christina, Heisterkamp Nora   +5 more
doaj   +3 more sources

Non-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factors. [PDF]

PLoS ONE, 2014
Non-muscle myosin II (NM II) regulates a wide range of cellular functions, including neuronal differentiation, which requires precise spatio-temporal activation of Rho GTPases.
Eun-Young Shin, Chan-Soo Lee, Cheong-Yong Yun, So-Yoon Won, Hyong-Kyu Kim, Yong Hee Lee, Sahng-June Kwak, Eung-Gook Kim   +7 more
doaj   +2 more sources

Structural biology of DOCK-family guanine nucleotide exchange factors. [PDF]

FEBS Lett, 2023
DOCK proteins are a family of multi‐domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase‐dependent cellular processes. DOCK proteins are characterized by the catalytic DHR2
Boland A, Côté JF, Barford D.
europepmc   +2 more sources

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain [PDF]

Molecular Brain, 2018
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain.
Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka   +6 more
doaj   +2 more sources

Editorial: Guanine nucleotide exchange factors as determinants of cell fate and development [PDF]

Frontiers in Cell and Developmental Biology
Vegesna Radha, Katsuhiko Tabuchi, Katsuhiko Tabuchi, Jacek Z. Kubiak, Jacek Z. Kubiak   +4 more
doaj   +2 more sources

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. [PDF]

J Biol Chem, 2021
The protein Lgl1 is a key regulator of cell polarity. We previously showed that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN tumour suppressor loss and aberrant activation of the PI 3-kinase pathway; this ...
Lavictoire SJ, Jomaa D, Gont A, Jardine K, Cook DP, Lorimer IAJ.   +5 more
europepmc   +2 more sources

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

Genetic analysis of GEFs and GDIs in rice reveals the roles of OsGEF5, OsGDI1, and OsGEF3 in the regulation of grain size and plant height

Crop Journal, 2023
Guanine nucleotide exchange factors (GEFs) and guanine nucleotide-dissociation inhibitors (GDIs) regulate small GTPase proteins, which function as molecular switches in various signaling pathways, but their identification and functions in plants are not ...
Munsif Ali Shad, Yixian Wang, Hui Zhang, Shanshan Zhai, Abdullah Shalmani, Yibo Li   +5 more
doaj   +1 more source

Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling. [PDF]

Small GTPases, 2021
Macrophages are important immune sentinels that detect and clear pathogens and initiate inflammatory responses through the activation of surface receptors, including Toll-like receptors (TLRs).
Tong SJ, Wall AA, Hung Y, Luo L, Stow JL.   +4 more
europepmc   +2 more sources