Results 1 to 10 of about 15,352 (140)
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Molecular Genetics and Genomics, 1995
In animals, the small GTP-binding proteins, Rac and Rho, of the ras superfamily participate in the signal transduction pathway that regulates the organization of the actin cytoskeleton. We report here on the characterization of two distinct cDNA clones isolated from a cotton fiber cDNA library that code for homologs of animal Rac proteins.
Deborah P Delmer, Delmer Deborah P
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In animals, the small GTP-binding proteins, Rac and Rho, of the ras superfamily participate in the signal transduction pathway that regulates the organization of the actin cytoskeleton. We report here on the characterization of two distinct cDNA clones isolated from a cotton fiber cDNA library that code for homologs of animal Rac proteins.
Deborah P Delmer, Delmer Deborah P
exaly +3 more sources
Free Radical Research, 2007
8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) has been regarded simply as a oxidative mutagenic byproduct. The results obtained in this study imply that it may act as a down-regulator of respiratory burst of neutrophils. Human neutrophils treated with PMA produced superoxides and at the same time, the cytosol of these cells was intensely ...
Hee Joon Kim +2 more
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8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) has been regarded simply as a oxidative mutagenic byproduct. The results obtained in this study imply that it may act as a down-regulator of respiratory burst of neutrophils. Human neutrophils treated with PMA produced superoxides and at the same time, the cytosol of these cells was intensely ...
Hee Joon Kim +2 more
exaly +3 more sources
Biochemical and Biophysical Research Communications, 1993
Rho p21 and rac p21 small GTP-binding proteins are regulated by the same inhibitory and stimulatory GDP/GTP exchange proteins termed rho GDI and smg GDS, respectively. RhoA p21 and rac1 p21 bind with similar affinities to rho GDI and both proteins also bind with similar affinities to smg GDS. RhoA p21 and rac1 p21 have similar GDP/GTP exchange rates in
T Nishiyama
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Rho p21 and rac p21 small GTP-binding proteins are regulated by the same inhibitory and stimulatory GDP/GTP exchange proteins termed rho GDI and smg GDS, respectively. RhoA p21 and rac1 p21 bind with similar affinities to rho GDI and both proteins also bind with similar affinities to smg GDS. RhoA p21 and rac1 p21 have similar GDP/GTP exchange rates in
T Nishiyama
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Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2
Science, 1991A major action of the microbicidal system of human neutrophils is the formation of superoxide anion (O 2 - ) by a multicomponent oxidase that transfers electrons from the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to molecular oxygen.
U G, Knaus +4 more
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Signal transduction through the GTP-binding proteins Rac and Rho
Journal of Cell Science, 1994ABSTRACT Actin reorganization is an early response to many extra- cellular factors. In Swiss 3T3 fibroblasts, the Ras-related GTP-binding proteins Rho and Rac act as key signal trans- ducers in these responses: Rho is required for growth factor-induced formation of stress fibres and focal adhesions, whereas membrane ruffling is regulated
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Biochemical and Biophysical Research Communications, 1990
Ras proteins can be modified at their COOH-terminal cysteine in the motif Cys-Ali-Ali-Xaa by a farnesyl isoprenoid. This modification is essential for membrane association and biological activity of ras proteins. A similar COOH-terminal amino acid sequence, Cys-Xaa-Ali-Xaa, exists in the ras-related GTP-binding proteins rac 1 and rac 2.
J R, Didsbury, R J, Uhing, R, Snyderman
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Ras proteins can be modified at their COOH-terminal cysteine in the motif Cys-Ali-Ali-Xaa by a farnesyl isoprenoid. This modification is essential for membrane association and biological activity of ras proteins. A similar COOH-terminal amino acid sequence, Cys-Xaa-Ali-Xaa, exists in the ras-related GTP-binding proteins rac 1 and rac 2.
J R, Didsbury, R J, Uhing, R, Snyderman
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International Journal of Oncology, 1997
The small GTP-binding protein rac-1 has been reported to be a mediator for tumor promoter, growth factor and serum-induced cell membrane ruffling. We have stably overexpressed rac-1 in JB6 P+ cells. In contrast to rac-1 expressing NIH/3T3 cells, all JB6 transfectants expressing rac-1 did not show tumorigenic transformation (forward progression) but ...
Z, Dong, M, Ding, W, Ma, N, Colburn
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The small GTP-binding protein rac-1 has been reported to be a mediator for tumor promoter, growth factor and serum-induced cell membrane ruffling. We have stably overexpressed rac-1 in JB6 P+ cells. In contrast to rac-1 expressing NIH/3T3 cells, all JB6 transfectants expressing rac-1 did not show tumorigenic transformation (forward progression) but ...
Z, Dong, M, Ding, W, Ma, N, Colburn
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Biochemical and Biophysical Research Communications, 1995
Membrane ruffling and the closely linked response of fluid-phase pinocytosis were investigated in Chinese hamster ovary cells that stably overexpress the human insulin receptor and a mutant 85-kDa subunit of phosphoinositide (PI) 3-kinase (delta p85) that lacks a binding site for the catalytic 110-kDa subunit of this enzyme.
K, Kotani +4 more
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Membrane ruffling and the closely linked response of fluid-phase pinocytosis were investigated in Chinese hamster ovary cells that stably overexpress the human insulin receptor and a mutant 85-kDa subunit of phosphoinositide (PI) 3-kinase (delta p85) that lacks a binding site for the catalytic 110-kDa subunit of this enzyme.
K, Kotani +4 more
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Biochemical and Biophysical Research Communications, 1994
Superoxide generation by phagocytic cells requires assembly of the enzymatic complex NADPH oxidase, consisting of membranous and cytosolic components which translocate to the plasma membrane upon cell activation. Two highly homologous cytosolic small GTP-binding proteins, rac1 and rac2, have recently been implicated in the activation of NADPH oxidase ...
Le Cabec, V. +3 more
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Superoxide generation by phagocytic cells requires assembly of the enzymatic complex NADPH oxidase, consisting of membranous and cytosolic components which translocate to the plasma membrane upon cell activation. Two highly homologous cytosolic small GTP-binding proteins, rac1 and rac2, have recently been implicated in the activation of NADPH oxidase ...
Le Cabec, V. +3 more
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Experimental and Clinical Endocrinology & Diabetes, 2009
Post-receptor signalling molecules that convey the signal from the activated insulin receptor to the actual process of Glut4 translocation and hexose uptake are poorly understood. Various studies have suggested a requirement of the lipid kinase phosphatidylinositol-3 kinase (PI3-kinase) in this process.
Dorrestijn, J. +3 more
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Post-receptor signalling molecules that convey the signal from the activated insulin receptor to the actual process of Glut4 translocation and hexose uptake are poorly understood. Various studies have suggested a requirement of the lipid kinase phosphatidylinositol-3 kinase (PI3-kinase) in this process.
Dorrestijn, J. +3 more
openaire +3 more sources