Results 21 to 30 of about 15,352 (140)
Frontiers in Immunology, 2022 Strategies based on intracellular expression of artificial binding domains present several advantages over manipulating nucleic acid expression or the use of small molecule inhibitors.
Laura Keller +14 more
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The small GTP-binding protein Rac is a regulator of cell death in plants [PDF]
Proceedings of the National Academy of Sciences, 1999 Cell death plays important roles in the development and defense of plants as in other multicellular organisms. Rapid production of reactive oxygen species often is associated with plant defense against pathogens, but their molecular mechanisms are not known.
T, Kawasaki +6 more
openaire +2 more sources
Thrombopoietin and collagen in low doses cooperatively induce human platelet activation
Acute Medicine & Surgery, 2022 Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi +13 more
doaj +1 more source
The role of statins in lung cancer
Archives of Medical Science, 2021 Lung cancer is one of the most common causes of cancer-related mortality in the 21st century. Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only reduce the cholesterol levels in the blood and decrease the risk of ...
Fatemeh Amin +4 more
doaj +1 more source
Viruses, 2022 Zika virus (ZIKV) infection during pregnancy can result in a significant impact on the brain and eye of the developing fetus, termed congenital zika syndrome (CZS).
Aidan J. Norbury +3 more
doaj +1 more source
Cell Communication and Signaling, 2021 Background Vascular endothelial barrier function is maintained by cell-to-cell junctional proteins and contributes to vascular homeostasis. Various risk factors such as inflammation disrupt barrier function through down-regulation of these proteins and ...
Kayo Kunimura +3 more
doaj +1 more source
Multiple Omics Analysis of the Rac3 Roles in Different Types of Human Cancer
IEEE Access, 2022 Rac Family Small GTPase 3 (Rac3) is a member of the Rho family of small GTP-binding proteins which play critical roles in the occurrence, progression, and metastasis of various tumors. Nevertheless, previous studies have focused on a single type of human
Yipeng Song, Rongna Ma
doaj +1 more source
Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac [PDF]
Molecular and Cellular Biology, 1998 The Mas oncogene encodes a novel G-protein-coupled receptor that was identified originally as a transforming protein when overexpressed in NIH 3T3 cells. The mechanism and signaling pathways that mediate Mas transformation have not been determined. We observed that the foci of transformed NIH 3T3 cells caused by Mas were similar to those caused by ...
I E, Zohn +4 more
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Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42
Cancer Research Communications, 2022 Rac and Cdc42, are homologous GTPases that regulate cell migration, invasion, and cell-cycle progression; thus, representing key targets for metastasis therapy. We previously reported on the efficacy of MBQ-167, which blocks both Rac1 and Cdc42 in breast cancer cells and mouse models of metastasis. To identify compounds with increased activity, a panel
Julia I. Medina +9 more
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BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac [PDF]
Proceedings of the National Academy of Sciences, 1998 The phenotype of hematopoietic cells transformed by the BCR/ABL oncoprotein of the Philadelphia chromosome is characterized by growth factor-independent proliferation, reduced susceptibility to apoptosis, and altered adhesion and motility. The mechanisms underlying this phenotype are not fully understood, but there is evidence that some of the ...
Skorski T +7 more
openaire +3 more sources