Results 31 to 40 of about 15,352 (140)

The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria. [PDF]

PLoS ONE, 2012
BACKGROUND: CEACAM3 is a granulocyte receptor mediating the opsonin-independent recognition and phagocytosis of human-restricted CEACAM-binding bacteria.
Stefan Pils, Kathrin Kopp, Lisa Peterson, Julia Delgado Tascón, Naja J Nyffenegger-Jann, Christof R Hauck   +5 more
doaj   +1 more source

Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]

PLoS ONE, 2010
The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann, Katrin Janik, Martin May, Kirsten Sommer, Jenny Ebeling, Fred Hofmann, Harald Genth, Andreas Klos   +7 more
doaj   +1 more source

Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation [PDF]

Journal of Biological Chemistry, 1996
Lethal toxin (LT) from Clostridium sordellii is one of the high molecular mass clostridial cytotoxins. On cultured cells, it causes a rounding of cell bodies and a disruption of actin stress fibers. We demonstrate that LT is a glucosyltransferase that uses UDP-Glc as a cofactor to covalently modify 21-kDa proteins both in vitro and in vivo.
M R, Popoff, E, Chaves-Olarte, E, Lemichez, C, von Eichel-Streiber, M, Thelestam, P, Chardin, D, Cussac, B, Antonny, P, Chavrier, G, Flatau, M, Giry, J, de Gunzburg, P, Boquet   +12 more
openaire   +2 more sources

Profiling Ten RHO GTPases in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations. [PDF]

Cancer Med
Expression of RHO GTPases in myeloid malignancies. Gene expression analysis of ten RHO GTPases revealed RHOBTB2, RND2, and RHOQ as differently expressed in patients with MDS and/or AML. RHOBTB2 was identified as a promising prognostic indicator. BM, bone marrow. MDS, myelodysplastic neoplasm. AML, acute myeloid leukemia.
de Almeida Rodrigues B, de Paiva LB, Ramalho MCC, Damasceno AF, Saad STO, Lazarini M.   +5 more
europepmc   +2 more sources

Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. [PDF]

Molecular Biology of the Cell, 1993
Rac1 and Rac2 are closely related, low molecular weight GTP-binding proteins that have both been implicated in regulation of phagocyte NADPH oxidase. This enzyme system is composed of multiple membrane-bound and cytosolic subunits and when activated catalyzes the one-electron reduction of oxygen to superoxide.
P G, Heyworth, U G, Knaus, X, Xu, D J, Uhlinger, L, Conroy, G M, Bokoch, J T, Curnutte   +6 more
openaire   +2 more sources

Rac-Related GTP-Binding Protein in Elicitor-Induced Reactive Oxygen Generation by Suspension-Cultured Soybean Cells [PDF]

Plant Physiology, 2000
Abstract Plant cells produce reactive oxygen species (ROS) in response to many stimuli. However, the mechanism of ROS biosynthesis remains unclear. We have explored the hypothesis that the superoxide burst in plants mechanistically resembles the oxidative burst in neutrophils.
Park, J, Choi, HT, Lee, S, Lee, T, Yang, ZB, Lee, Y   +5 more
openaire   +3 more sources

The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes [PDF]

Current Biology, 1995
In insulin-sensitive cells, such as adipocytes and skeletal muscle, the activation of phosphoinositide 3-kinase (PI 3-kinase) is thought to be critical in allowing insulin to stimulate both the uptake of glucose and the translocation of a specialized glucose transporter, GLUT4, to the plasma membrane.
Marcusohn, J., Isakoff, S.J., Rose, E., Symons, M., Skolnik, E.Y.   +4 more
openaire   +2 more sources

Distinct CED-10/Rac1 domains confer context-specific functions in development.

PLoS Genetics, 2018
Rac GTPases act as master switches to coordinate multiple interweaved signaling pathways. A major function for Rac GTPases is to control neurite development by influencing downstream effector molecules and pathways.
Steffen Nørgaard, Shuer Deng, Wei Cao, Roger Pocock   +3 more
doaj   +1 more source

Rac and Rho GTPases in cancer cell motility control

Cell Communication and Signaling, 2010
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation.
Parri Matteo, Chiarugi Paola
doaj   +1 more source

Involvement of the Small GTPase Rac in the Defense Responses of Tobacco to Pathogens

Molecular Plant-Microbe Interactions, 2005
During the hypersensitive response (HR), plants accumulate reactive oxygen species (ROS) that are likely generated at least in part by an NADPH oxidase similar to that found in mammalian neutrophils.
Wolfgang Moeder, Keiko Yoshioka, Daniel F. Klessig   +2 more
doaj   +1 more source