Results 21 to 30 of about 41,746 (257)

Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling. [PDF]

Small GTPases, 2021
Macrophages are important immune sentinels that detect and clear pathogens and initiate inflammatory responses through the activation of surface receptors, including Toll-like receptors (TLRs).
Tong SJ, Wall AA, Hung Y, Luo L, Stow JL.   +4 more
europepmc   +2 more sources

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

Genetic analysis of GEFs and GDIs in rice reveals the roles of OsGEF5, OsGDI1, and OsGEF3 in the regulation of grain size and plant height

Crop Journal, 2023
Guanine nucleotide exchange factors (GEFs) and guanine nucleotide-dissociation inhibitors (GDIs) regulate small GTPase proteins, which function as molecular switches in various signaling pathways, but their identification and functions in plants are not ...
Munsif Ali Shad, Yixian Wang, Hui Zhang, Shanshan Zhai, Abdullah Shalmani, Yibo Li   +5 more
doaj   +1 more source

Role of ARHGEF3 as a GEF and mTORC2 Regulator

Frontiers in Cell and Developmental Biology, 2022
Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq, Sana Abdul Khaliq, Zobia Umair, Mee-Sup Yoon, Mee-Sup Yoon, Mee-Sup Yoon   +5 more
doaj   +1 more source

Targeting Rac and Cdc42 GEFs in Metastatic Cancer

Frontiers in Cell and Developmental Biology, 2020
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado, Julia Isabel Medina, Luis Velazquez, Suranganie Dharmawardhane   +3 more
doaj   +1 more source

EspM2 is a RhoA guanine nucleotide exchange factor [PDF]

Cellular Microbiology, 2010
We investigated how the type III secretion system WxxxE effectors EspM2 of enterohaemorrhagic Escherichia coli, which triggers stress fibre formation, and SifA of Salmonella enterica serovar Typhimurium, which is involved in intracellular survival, modulate Rho GTPases.
Arbeloa, A, Garnett, J, Lillington, J, Bulgin, RR, Berger, CN, Lea, SM, Matthews, S, Frankel, G   +7 more
openaire   +3 more sources

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes [PDF]

Cellular Logistics, 2013
Paul A Randazzo, Xiaoying Jian, Pei-Wen Chen   +2 more
exaly   +2 more sources

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Frontiers in Molecular Biosciences, 2021
RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka, Yoshihisa Hirota, Yoshihisa Hirota, Doshun Ito, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Toshiya Senda, Toshiya Senda, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki   +18 more
doaj   +1 more source

Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma

Molecular & Cellular Oncology, 2021
In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells.
Mariana Cooke
doaj   +1 more source

A cytohesin homolog in Dictyostelium amoebae. [PDF]

, 2010
Dictyostelium, an amoeboid motile cell, harbors several paralogous Sec7 genes that encode members of three distinct subfamilies of the Sec7 superfamily of Guanine nucleotide exchange factors.
Kolanus, Waldemar, Müller, Rolf, Rosemarie Blau-Wasser, Blau-Wasser, Rosemarie, Glöckner, Gernot, Angelika A Noegel, Noegel, Angelika A., Gernot Glöckner, Rolf Müller, Michael Schleicher, Eichinger, Ludwig, Schleicher, Michael, Maria Christina Shina, Waldemar Kolanus, Ludwig Eichinger, Shina, Maria Christina   +15 more
core   +1 more source