Results 21 to 30 of about 9,354,840 (235)

Role of ARHGEF3 as a GEF and mTORC2 Regulator

Frontiers in Cell and Developmental Biology, 2022
Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq, Sana Abdul Khaliq, Zobia Umair, Mee-Sup Yoon, Mee-Sup Yoon, Mee-Sup Yoon   +5 more
doaj   +1 more source

Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases. [PDF]

J Biol Chem, 2013
Cabrera M, Ungermann C.
europepmc   +2 more sources

Targeting Rac and Cdc42 GEFs in Metastatic Cancer

Frontiers in Cell and Developmental Biology, 2020
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado, Julia Isabel Medina, Luis Velazquez, Suranganie Dharmawardhane   +3 more
doaj   +1 more source

Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (APC)–Rho-Guanine-Nucleotide-Exchange-Factor‑4 (Asef) Interaction

, 2018
In colorectal cancer, adenomatous polyposis coli (APC) interacts with Rho guanine-nucleotide-exchange factor 4 (Asef), thereby stimulating aberrant colorectal-cancer-cell migration.
Kun Song (522456), Jianrong Xu (297099), Jie Zhong (39213), Xiuyan Yang (174235), Ke Ding (309244), Cong Ruan (5643581), Jinxing Qian (5643578), Qiufen Zhang (2578927), Jian Zhang (1682)   +8 more
core   +3 more sources

EspM2 is a RhoA guanine nucleotide exchange factor [PDF]

Cellular Microbiology, 2010
We investigated how the type III secretion system WxxxE effectors EspM2 of enterohaemorrhagic Escherichia coli, which triggers stress fibre formation, and SifA of Salmonella enterica serovar Typhimurium, which is involved in intracellular survival, modulate Rho GTPases.
Arbeloa, A, Garnett, J, Lillington, J, Bulgin, RR, Berger, CN, Lea, SM, Matthews, S, Frankel, G   +7 more
openaire   +3 more sources

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Frontiers in Molecular Biosciences, 2021
RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka, Yoshihisa Hirota, Yoshihisa Hirota, Doshun Ito, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Toshiya Senda, Toshiya Senda, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki   +18 more
doaj   +1 more source

Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma

Molecular & Cellular Oncology, 2021
In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells.
Mariana Cooke
doaj   +1 more source

A cytohesin homolog in Dictyostelium amoebae. [PDF]

, 2010
Dictyostelium, an amoeboid motile cell, harbors several paralogous Sec7 genes that encode members of three distinct subfamilies of the Sec7 superfamily of Guanine nucleotide exchange factors.
Kolanus, Waldemar, Müller, Rolf, Rosemarie Blau-Wasser, Blau-Wasser, Rosemarie, Glöckner, Gernot, Angelika A Noegel, Noegel, Angelika A., Gernot Glöckner, Rolf Müller, Michael Schleicher, Eichinger, Ludwig, Schleicher, Michael, Maria Christina Shina, Waldemar Kolanus, Ludwig Eichinger, Shina, Maria Christina   +15 more
core   +2 more sources

The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans [PDF]

, 2013
Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Anne Spang, Ackema, K. B., Jachen A Solinger, Karin B Ackema, Ursula Sauder, Solinger, J. A., Karin B. Ackema, Jachen A. Solinger (254344), Jachen A. Solinger, Karin B. Ackema (423507), Ursula Sauder (250540), Spang, A., Anne Spang (205738), Sauder, U.   +13 more
core   +2 more sources

Structural biology of DOCK-family guanine nucleotide exchange factors. [PDF]

, 2022
DOCK proteins are a family of multi-domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase-dependent cellular processes.

core   +3 more sources