Results 41 to 50 of about 9,354,840 (235)

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis

Frontiers in Immunology, 2023
IntroductionRac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control the adhesion molecules and cytoskeletal dynamics required for neutrophil recruitment to inflamed and infected organs ...
Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch   +11 more
doaj   +1 more source

Alsin Is a Rab5 and Rac1 Guanine Nucleotide Exchange Factor [PDF]

Journal of Biological Chemistry, 2004
ALS2 is the gene mutated in a recessive juvenile form of amyotrophic lateral sclerosis (ALS2). ALS2 encodes a large protein termed alsin, which contains a number of predicted cell signaling and protein trafficking sequence motifs. To gain insight into the overall function of alsin and to begin to evaluate its role in motor neuron maintenance, we ...
Justin D, Topp, Noah W, Gray, Robert D, Gerard, Bruce F, Horazdovsky   +3 more
openaire   +2 more sources

The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. [PDF]

PLoS ONE, 2011
Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem.
Melissa C Srougi, Keith Burridge
doaj   +1 more source

The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication [PDF]

Journal of Virology, 2019
Rotavirus, a member of the family Reoviridae , is the major cause of severe diarrhea in children and young animals worldwide. Despite significant advances in the characterization of the biology of this virus, the mechanisms involved in morphogenesis of the virus particle are still poorly ...
Martínez, José L, Arnoldi, Francesca, Schraner, Elisabeth M, Eichwald, Catherine, Silva-Ayala, Daniela, Lee, Eunjoo, Sztul, Elizabeth, Burrone, Óscar R, López, Susana, Arias, Carlos F   +9 more
openaire   +4 more sources

Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5

Life Science Alliance, 2019
The structure of the SH3BP5–Rab11a complex and structure-based mutational analyses reveal structural basis of nucleotide exchange for Rab11 by its specific guanine nucleotide exchange factor. The Rab GTPase family is a major regulator of membrane traffic
Sakurako Goto-Ito, Nobukatsu Morooka, Atsushi Yamagata, Yusuke Sato, Ken Sato, Shuya Fukai   +5 more
doaj   +1 more source

P‐Rex2, a new guanine‐nucleotide exchange factor for Rac [PDF]

FEBS Letters, 2004
We have identified a new guanine‐nucleotide exchange factor, P‐Rex2, and cloned it from human skeletal muscle and brain libraries. It has widespread tissue distribution but is not expressed in neutrophils. P‐Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)‐trisphosphate and the βγ subunits ...
Donald, Sarah, Hill, Kirsti, Lecureuil, Charlotte, Barnouin, Romain, Krugmann, Sonja, John Coadwell, W., Andrews, Simon R., Walker, Simon A., Hawkins, Phillip T., Stephens, Len R., Welch, Heidi C.E.   +10 more
openaire   +2 more sources

VAV3 (vav 3 guanine nucleotide exchange factor) [PDF]

, 2011
Review on VAV3 (vav 3 guanine nucleotide exchange factor), with data on DNA, on the protein encoded, and where the gene is ...
Burnstein, KL, KL Burnstein, Lyons, L, Burnstein, K L, L Lyons   +4 more
core   +1 more source

S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange [PDF]

, 2003
Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of
Kamesh Pappu, Jason G. Williams, Pappu, K., Sharon L. Campbell, Williams, J. G., Campbell, S. L.   +5 more
core   +1 more source

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Nature Communications, 2017
Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and ...
Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco, Mikel Garcia-Marcos   +14 more
doaj   +1 more source

Asymmetric Coiled-Coil Structure with Guanine Nucleotide Exchange Activity [PDF]

, 2007
SummaryVesicular traffic during exocytosis is regulated by Rab GTPase, Sec4p in yeast, which is activated by a guanine nucleotide exchange factor (GEF) called Sec2p.
Sato, Yusuke, Shirakawa, Ryutaro, Horiuchi, Hisanori, Fukai, Shuya, Naoshi Dohmae, Shuya Fukai, Osamu Nureki, Nureki, Osamu, Dohmae, Naoshi, Yusuke Sato, Hisanori Horiuchi, Ryutaro Shirakawa   +11 more
core   +1 more source