Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5
Life Science Alliance, 2019 The structure of the SH3BP5–Rab11a complex and structure-based mutational analyses reveal structural basis of nucleotide exchange for Rab11 by its specific guanine nucleotide exchange factor. The Rab GTPase family is a major regulator of membrane traffic
Sakurako Goto-Ito +5 more
doaj +1 more source
Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis [PDF]
, 2017 Naegleria fowleri (N. fowleri) causes primary amoebic meningoencephalitis, a rapidly fatal disease of the central nervous system. N. fowleri can exist in cyst, flagellate or amoebic forms, depending on environmental conditions.
Cabral, Guy A +4 more
core +2 more sources
Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation
Angewandte Chemie, EarlyView.CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova +2 more
wiley +2 more sources
EspM2 is a RhoA guanine nucleotide exchange factor [PDF]
Cellular Microbiology, 2010 We investigated how the type III secretion system WxxxE effectors EspM2 of enterohaemorrhagic Escherichia coli, which triggers stress fibre formation, and SifA of Salmonella enterica serovar Typhimurium, which is involved in intracellular survival, modulate Rho GTPases.
Arbeloa, A +7 more
openaire +4 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Sequence‐Encoded Frustration Directs the Formation of Abridged G‐Quadruplex Architectures
Angewandte Chemie, EarlyView.Programmable frustration reshapes the free‐energy surface (FES) of guanine‐quadruplex (G4) folding, stabilizing an abridged G4 and a G‐triplex intermediate. ABSTRACT Frustration—competing interactions that cannot be simultaneously optimized—shapes energy landscapes in proteins and soft matter, but has rarely been exploited as a programmable design ...
Yuncheng Qian +6 more
wiley +2 more sources
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
Nature Communications, 2018 Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood.
Meredith L. Jenkins +8 more
doaj +1 more source
High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]
, 2017 Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S. +5 more
core +2 more sources
This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
Frontiers in Cell and Developmental Biology, 2018 Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission.
Christopher Stroupe
doaj +1 more source
Mechanism of the exchange reaction in HRAS from multiscale modeling. [PDF]
PLoS ONE, 2014 HRAS regulates cell growth promoting signaling processes by cycling between active (GTP-bound) and inactive (GDP-bound) states. Understanding the transition mechanism is central for the design of small molecules to inhibit the formation of RAS-driven ...
Abhijeet Kapoor, Alex Travesset
doaj +1 more source