Results 41 to 50 of about 41,746 (257)
Structural biology of DOCK-family guanine nucleotide exchange factors.
, 2022 DOCK proteins are a family of multi-domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase-dependent cellular processes.
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Alsin Is a Rab5 and Rac1 Guanine Nucleotide Exchange Factor [PDF]
Journal of Biological Chemistry, 2004 ALS2 is the gene mutated in a recessive juvenile form of amyotrophic lateral sclerosis (ALS2). ALS2 encodes a large protein termed alsin, which contains a number of predicted cell signaling and protein trafficking sequence motifs. To gain insight into the overall function of alsin and to begin to evaluate its role in motor neuron maintenance, we ...
Justin D, Topp +3 more
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Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]
, 2004 Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T +3 more
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Frontiers in Immunology, 2023 IntroductionRac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control the adhesion molecules and cytoskeletal dynamics required for neutrophil recruitment to inflamed and infected organs ...
Polly A. Machin +11 more
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The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. [PDF]
PLoS ONE, 2011 Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem.
Melissa C Srougi, Keith Burridge
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Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5
Life Science Alliance, 2019 The structure of the SH3BP5–Rab11a complex and structure-based mutational analyses reveal structural basis of nucleotide exchange for Rab11 by its specific guanine nucleotide exchange factor. The Rab GTPase family is a major regulator of membrane traffic
Sakurako Goto-Ito +5 more
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Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
Nature Communications, 2017 Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and ...
Alain Ibáñez de Opakua +14 more
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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
Nature Communications, 2018 Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood.
Meredith L. Jenkins +8 more
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This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
Frontiers in Cell and Developmental Biology, 2018 Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission.
Christopher Stroupe
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Mechanism of the exchange reaction in HRAS from multiscale modeling. [PDF]
PLoS ONE, 2014 HRAS regulates cell growth promoting signaling processes by cycling between active (GTP-bound) and inactive (GDP-bound) states. Understanding the transition mechanism is central for the design of small molecules to inhibit the formation of RAS-driven ...
Abhijeet Kapoor, Alex Travesset
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