Results 271 to 280 of about 320,673 (337)

Guanine-Quadruplex-EngineeredcrRNA Enables Light-ActivatedCRISPR/Cas12a System for Robust One-Pot Viral Assay

open access: green
Jinlian Du (14333045)   +12 more
openalex   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

open access: yesInsect Science, EarlyView.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola   +15 more
wiley   +1 more source

The mechanism of thioamide formation by the YcfA-YcfC system in 6-thioguanine biosynthesis. [PDF]

open access: yesNat Commun
Zhang L   +10 more
europepmc   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

open access: yesAndrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby   +10 more
wiley   +1 more source

Study on the Binding of Five Plant-Derived Secondary Metabolites to G‑Quadruplexes. [PDF]

open access: yesACS Omega
Vrtalová L   +5 more
europepmc   +1 more source

Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

open access: yesBritish Journal of Haematology, EarlyView.
We show how the loss of activity of the translation initiation factor EIF5A2—either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post‐translational modification—induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.
Eva Crespo‐García   +5 more
wiley   +1 more source

Detecting polynucleotide motifs: Pentads, hexads, and beyond. [PDF]

open access: yesPLoS Comput Biol
Zurkowski M   +3 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Computational Analysis of a Next-Generation Platinum-Based Chemotherapies that Induce DNA Double-Strand Breaks. [PDF]

open access: yesJ Chem Inf Model
Guimarães AR   +9 more
europepmc   +1 more source

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