Results 281 to 290 of about 320,673 (337)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

New biochemical approaches for the treatment of glioblastoma. [PDF]

J Biol Chem
Lindsey-Boltz LA, Sancar A.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Disruption of purine <i>de novo</i> synthesis pathway impairs membrane homeostasis, intracellular survival, and virulence of <i>Brucella melitensis</i>. [PDF]

Front Microbiol
Yang G, Li M, Li Y, Chen S, Qu J, Li J, Wang S, Bao Y, Qi J, Dou Y, Tian M.   +10 more
europepmc   +1 more source

A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer

Florian Dilasser, Lindsay Rose, Agnès Quéméner, Yann Ferrandez, Dorian Hassoun, Morgane Rousselle, Hugo Bergereau, Séverine Marionneau Lambot, Luciano Anselmino, Camille Trouillet, Gwennan André‐Grégoire, Mike Maillasson, Mikaël Croyal, Matthieu Rivière, Didier Dubreuil, Sylvain Collet, Frédérique Souazé, Mario Campone, Anne Patsouris, Erwan Mortier, Mauricio Menacho-Márquez, Philippe Juin, Jacques Lebreton, Agnès Tessier, Jacqueline Cherfils, Gervaise Loirand, Vincent Sauzeau   +26 more
openalex   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Agent-specific DNA repair kinetic in 3T3 cells: a comparative study using the in vitro comet assay. [PDF]

Toxicol Res (Camb)
İpek Tekneci S, Üstündağ A, Duydu Y.
europepmc   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch. [PDF]

J Am Chem Soc
Li C, Yang X, Dickerson KA, Zanon PRA, Springer NA, Wang J, Jia Y, Munshi NC, Batey RT, Disney MD.   +9 more
europepmc   +1 more source

Crystal structures reveal the distinct features of the 2'-dG-III riboswitch in the purine riboswitch family. [PDF]

Nucleic Acids Res
Chen K, Liao W, Wang J, Ren Y, Lu Z, Peng X, Wang J, Huang L.   +7 more
europepmc   +1 more source