Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 [PDF]
Nature Communications, 2018 Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood.
Meredith L. Jenkins +8 more
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Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1. [PDF]
Small GTPases, 2021 Since the discovery by Madaule and Axel in 1985 of the first Ras homologue (Rho) protein in Aplysia and its human orthologue RhoB, membership in the Rho GTPase family has grown to 20 proteins, with representatives in all eukaryotic species. These GTPases
Joo E, Olson MF.
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Retraction: Gonzalez, G.; Chen, L. EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor. Cells 2021, 10, 1325 [PDF]
Cells, 2022 The journal retracts the article “Retraction: Gonzalez, G.; Chen, L. EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor” [...]
Gilberto Gonzalez, Lizhen Chen
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Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22. [PDF]
PLoS ONE, 2015 Legionella pneumophila, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery.
Young-Sik Sohn +9 more
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Nature Communications, 2017 The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism and ...
Stephan Kiontke +6 more
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Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 [PDF]
Nature Communications, 2020 Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and ...
Levi J. McClelland +13 more
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Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain [PDF]
iScienceSummary: Although most members of the Rho guanine nucleotide exchange factor (RhoGEF) family are found to be phosphorylated, how phosphorylation regulates RhoGEF function is poorly understood.
Jesus F. Moreno +9 more
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Gβγ mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression. [PDF]
J Biol Chem, 2022 García-Jiménez I +7 more
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Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells [PDF]
Immunity & Ageing, 2012 Background We recently isolated and identified Zizimin2 as a functional factor that is highly expressed in murine splenic germinal center B cells after immunization with T-cell-dependent antigen.
Sakabe Isamu +3 more
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Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses [PDF]
Viruses, 2020 The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
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