Retraction: Gonzalez, G.; Chen, L. EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor. Cells 2021, 10, 1325 [PDF]
Cells, 2022 The journal retracts the article “Retraction: Gonzalez, G.; Chen, L. EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor” [...]
Gilberto Gonzalez, Lizhen Chen
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Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1 [PDF]
Nature Communications, 2017 The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism and ...
Stephan Kiontke +6 more
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The Guanine Nucleotide Exchange Factor RIC8 Regulates Conidial Germination through Gα Proteins in Neurospora crassa [PDF]
, 2012 Heterotrimeric G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crassa. We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and
Carla J. Eaton +5 more
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Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 [PDF]
Nature Communications, 2020 Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and ...
Levi J. McClelland +13 more
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Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain [PDF]
iScienceSummary: Although most members of the Rho guanine nucleotide exchange factor (RhoGEF) family are found to be phosphorylated, how phosphorylation regulates RhoGEF function is poorly understood.
Jesus F. Moreno +9 more
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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 [PDF]
Nature Communications, 2018 Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood.
Meredith L. Jenkins +8 more
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Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses [PDF]
Viruses, 2020 The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
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Scambio, a novel guanine nucleotide exchange factor for Rho
Molecular Cancer, 2004 Background Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis.
Groffen John +5 more
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β-PIX-d, a Member of the ARHGEF7 Guanine Nucleotide Exchange Factor Family, Activates Rac1 and Induces Neuritogenesis in Primary Cortical Neurons. [PDF]
Exp NeurobiolKim S +5 more
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The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways. [PDF]
Exp Mol MedKim JA +8 more
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