Results 91 to 100 of about 93,566 (291)
Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
Biologics: Targets & Therapy, 2016 Jie Shi, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, People’s Republic of China Abstract: Guanine nucleotide exchange ...
Shi J +5 more
doaj
The Emerging Role of Guanine Exchange Factors in ALS and other neurodegenerative diseases
Frontiers in Cellular Neuroscience, 2014 Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide ...
Cristian eDroppelmann +5 more
doaj +1 more source
Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption [PDF]
, 2019 Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs)
Cha, Young-Nam +6 more
core +2 more sources
Identification of novel genes regulating the development of the palate
Developmental Dynamics, EarlyView.Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley +1 more source
eLife, 2019 Dendritic arbors are crucial for nervous system assembly, but the intracellular mechanisms that govern their assembly remain incompletely understood.
Leo TH Tang +6 more
doaj +1 more source
The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]
, 2016 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
core +2 more sources
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Nature Communications, 2017 The guanine nucleotide exchange factor SOS is a critical intermediary that transduces receptor tyrosine kinase stimulation into Ras activation. Here the authors develop a single molecule assay in which SOS is captured from raw lysates using Ras ...
Young Kwang Lee +6 more
doaj +1 more source
β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
Nature Communications, 2020 Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly,
Tatiana Omelchenko +2 more
doaj +1 more source