Results 101 to 110 of about 90,710 (248)
β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
Nature Communications, 2020 Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly,
Tatiana Omelchenko +2 more
doaj +1 more source
Bioanalytical TERS and Advanced Data Processing Methods
Journal of Raman Spectroscopy, EarlyView.Tip‐enhanced Raman spectroscopy delivers label‐free, subnanometer vibrational imaging of biological systems. Recent advances in instrumentation, data analysis, and ambient/liquid operation enable surface‐selective mapping of molecular heterogeneity in proteins, nucleic acids, membranes, and viruses, positioning TERS as a powerful platform for nanoscale
Sarika Joshi +6 more
wiley +1 more source
SGEF is a potential prognostic and therapeutic target for lung adenocarcinoma
World Journal of Surgical Oncology, 2018 Background SH3-containing guanine nucleotide exchange factor (SGEF), a RhoG-specific guanine nucleotide exchange factor (GEF), was consider as a key signal that determines cancer cell invasion.
Qian Chen +6 more
doaj +1 more source
The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]
, 2016 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
core +2 more sources
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
PAKing up to the endothelium [PDF]
, 2009 Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte +3 more
core +6 more sources
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae +6 more
wiley +1 more source
Pest Management Science, EarlyView.RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden +3 more
wiley +1 more source
EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5 [PDF]
, 2013 Background: Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells.
Buday, László +5 more
core +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source