Results 121 to 130 of about 105,827 (294)

Observation of coherent delocalized phonon-like modes in DNA under physiological conditions [PDF]

, 2016
Underdamped terahertz-frequency delocalized phonon-like modes have long been suggested to play a role in the biological function of DNA. Such phonon modes involve the collective motion of many atoms and are prerequisite to understanding the molecular ...
Ellis, Elizabeth M., González-Jiminéz, Mario, Harwood, Thomas, Kelly, Sharon M., Lapthorn, Adrian J., Ramakrishnan, Gopakumar, Wynne, Klaas   +6 more
core   +1 more source

A Robust Immunohistochemistry‐Based Classification for BRAF V600E‐Mutant Colorectal Cancer With Clinical Implications

Cancer Science, EarlyView.
This study develops an immunohistochemistry (IHC)‐based classification system for BRAF V600E‐mutant colorectal cancer, enabling practical stratification into iBM1 and iBM2 subtypes using CD8 and ARHGEF17 markers. The IHC‐defined subtypes demonstrated concordance with transcriptomic BM1/BM2 classifications and reflected distinct molecular and immune ...
Chao Liu, Yuli Ruan, Tong Wu, Xindi Luan, Yue Ma, Hong Wang, Tianjiao Dang, Yiwen Ou, Bojun Wang, Chunhui Zhang, Hongxue Meng, Yanqiao Zhang   +11 more
wiley   +1 more source

The Guanine Nucleotide Exchange Factor p63RhoGEF, a Specific Link between Gq/11-coupled Receptor Signaling and RhoA*

Journal of Biological Chemistry, 2005
The monomeric GTPase RhoA, which is a key regulator of numerous cellular processes, is activated by a variety of G protein-coupled receptors, through either G12 or Gq family proteins.
S. Lutz, Andrea Freichel-Blomquist, Yang Yang, U. Rümenapp, K. Jakobs, Martina Schmidt, T. Wieland   +6 more
semanticscholar   +1 more source

Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]

, 2009
The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

A Rab8 Guanine Nucleotide Exchange Factor-Effector Interaction Network Regulates Primary Ciliogenesis*

Journal of Biological Chemistry, 2012
Background: Exocytosis at the plasma membrane mediated by Rabin8 is essential for primary ciliogenesis. Results: Rabin8 activation involves the relief of its autoinhibition.
S. Feng, A. Knödler, Jinqi Ren, Jian Zhang, Xiaoyu Zhang, Yujuan Hong, Shaohui Huang, J. Peränen, Wei Guo   +8 more
semanticscholar   +1 more source

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]

, 2013
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Wöhnert, Jens   +5 more
core   +1 more source

Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells

Cell Proliferation, EarlyView.
The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li, Hongyun Duan, Lu Yang, Lingyi Jiang, Haocheng Bian, Yuqin Jiang, Yixi Zhang, Wei Yan, Qin Yang, Tingting Li, Xiang Qin, Zong‐Yuan Liu, Ningwei Sun, Kai‐fu Yang, Yiyao Liu   +14 more
wiley   +1 more source

The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer [PDF]

, 2008
Jane Lane, Tracey A. Martin, Robert E. Mansel, Wen G. Jiang   +3 more
openalex   +1 more source

The Sec7 Guanine Nucleotide Exchange Factor GBF1 Regulates Membrane Recruitment of BIG1 and BIG2 Guanine Nucleotide Exchange Factors to the Trans-Golgi Network (TGN)*

Journal of Biological Chemistry, 2013
Background: GBF1, BIG1, and BIG2 are guanine nucleotide exchange factors (GEFs) that activate ARFs to regulate secretory traffic. Results: GBF1 activity promotes subsequent recruitment of BIG1/2.
Jason Lowery, T. Szul, M. Styers, Zoe G. Holloway, V. Oorschot, J. Klumperman, E. Sztul   +6 more
semanticscholar   +1 more source