Results 131 to 140 of about 93,566 (291)

Mutations at position 1122 in the catalytic domain of the mouse ras‐specific guanine nucleotide exchange factor CDC25^Mm originate both loss‐of‐function and gain‐of‐function proteins [PDF]

, 1998
Vittorio Carrera, Andrea Moroni, Enzo Martegani, Celina Volponi, Robbert H. Cool, Lilia Alberghina, Marco Vanoni   +6 more
openalex   +1 more source

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration [PDF]

, 2016
Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Maček, Angeliki Malliri   +7 more
openalex   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

βPix Guanine Nucleotide Exchange Factor Regulates Regeneration of Injured Peripheral Axons. [PDF]

Int J Mol Sci, 2023
Jeon Y, Shin YK, Kim H, Choi YY, Kang M, Kwon Y, Cho Y, Chi SW, Shin JE.   +8 more
europepmc   +1 more source

Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors [PDF]

, 2013
Xun Shang, Fillipo Marchioni, Chris R. Evelyn, Nisha S. Sipes, Xuan Zhou, William Seibel, Matthew D. Wortman, Yi Zheng   +7 more
openalex   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling. [PDF]

J Exp Med, 2023
Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N.   +20 more
europepmc   +1 more source

Arf6 Guanine Nucleotide Exchange Factor Cytohesin-2 Binds to CCDC120 and Is Transported Along Neurites to Mediate Neurite Growth [PDF]

, 2014
Tomohiro Torii, Yuki Miyamoto, Kenji Tago, Kazunori Sango, Kazuaki Nakamura, Atsushi Sanbe, Akito Tanoue, Junji Yamauchi   +7 more
openalex   +1 more source

Use of high throughput sequencing to observe genome dynamics at a single cell level

, 2009
With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced
A. Soldatov, Bentley, Benzer, Bhanot, Cai, Cairns, Cox, Cupples, D. Parkhomchuk, Dotsch, Elowitz, Foster, Foster, Gabriel, Goodarzi, Hall, Hill-Perkins, Lindahl, Loechler, Loveless, Meselson, Mitra, Niki, Raser, Rosche, Sedgwick, Singer, V. Amstislavskiy, V. Ogryzko, Yu   +29 more
core   +1 more source