Results 151 to 160 of about 90,710 (248)

Advances and opportunities for computational interrogation of plant proteins

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate.
Sarah M. Bohling, Shaila Musharoff, Laura H. Gunn   +2 more
wiley   +1 more source

The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN. [PDF]

J Biol Chem, 2022
Nakano S, Nishikawa M, Kobayashi T, Harlin EW, Ito T, Sato K, Sugiyama T, Yamakawa H, Nagase T, Ueda H.   +9 more
europepmc   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Correction: The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila. [PDF]

PLoS One, 2021
Chang YJ, Zhou L, Binari R, Manoukian A, Mak T, McNeill H, Stambolic V.   +6 more
europepmc   +1 more source

Mycobacterium smegmatis MfpC is a GEF that regulates mfpA translationally to alter the fluoroquinolone efficacy

Communications Biology
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a serious threat to global public health. Fluoroquinolones (FQs) are effective against M. tuberculosis; however, resistant strains have limited their efficacy.
Yu Huang, Qinglei Shen, Hongxiang Xu, Lingxi Huang, Shasha Xiang, Peibo Li, Lin Fan, Jianping Xie   +7 more
doaj   +1 more source

Barley guanine nucleotide exchange factor HvGEF14 is an activator of the susceptibility factor HvRACB and supports host cell entry by Blumeria graminis f. sp. hordei. [PDF]

Mol Plant Pathol, 2022
Trutzenberg A, Engelhardt S, Weiß L, Hückelhoven R.   +3 more
europepmc   +1 more source

Gβγ mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression. [PDF]

J Biol Chem, 2022
García-Jiménez I, Cervantes-Villagrana RD, Del-Río-Robles JE, Castillo-Kauil A, Beltrán-Navarro YM, García-Román J, Reyes-Cruz G, Vázquez-Prado J.   +7 more
europepmc   +1 more source

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Maternal choline supplementation (MCS) is utilized in the Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD). At ~6 months of age, laser capture microdissection and single population RNA‐sequencing of three hippocampal neuron populations (CA1 and CA3 pyramidal neurons and dentate gyrus granule cells) were conducted.
Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg   +8 more
wiley   +1 more source

Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication. [PDF]

J Biol Chem, 2022
Ide M, Tabata N, Yonemura Y, Shirasaki T, Murai K, Wang Y, Ishida A, Okada H, Honda M, Kaneko S, Doi N, Ito S, Yanagawa H.   +12 more
europepmc   +1 more source

Controlled Delivery and Light‐Induced Release of Magic Spot Nucleotides in Escherichia coli

Angewandte Chemie International Edition, Volume 65, Issue 15, 6 April 2026.
We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp, Patrick Moser, Anselm Schwoerbel, Xinwei Liu, Johannes Freitag, Pinku Sarmah, Isabel Prucker, Robert Zscherp, Xuan Wang, Philipp Klahn, Hans‐Georg Koch, Gert Bange, Henning J. Jessen   +12 more
wiley   +1 more source