Results 181 to 190 of about 105,827 (294)

Phenotype and genotype spectrum of variants in guanine nucleotide exchange factor genes in a broad cohort of Iranian patients. [PDF]

Mol Genet Genomic Med, 2022
Mosallaei M, Ehtesham N, Beheshtian M, Khoshbakht S, Davarnia B, Kahrizi K, Najmabadi H.   +6 more
europepmc   +1 more source

Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Background Inflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
Siem J. de Haan, Jaap D. van Buul
wiley   +1 more source

Dual Interaction of ADP Ribosylation Factor 1 with Sec7 Domain and with Lipid Membranes during Catalysis of Guanine Nucleotide Exchange [PDF]

, 1999
Sophie Béraud-Dufour, S Paris, Marc Chabre, Bruno Antonny   +3 more
openalex   +1 more source

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, Volume 116, Issue 12, Page 3250-3265, December 2025.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Loss of neuronal βPix isoforms impairs neuronal morphology in the hippocampus and causes behavioral defects

Animal Cells and Systems
βPix is a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases, which play important roles in dendritic spine morphogenesis by modulating actin cytoskeleton organization.
Younghee Kwon, Seung Joon Lee, Yoon Kyung Shin, June-Seek Choi, Dongeun Park, Jung Eun Shin   +5 more
doaj   +1 more source

Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process

, 2022
Yuqing Xiong, Juan Zeng, Fei Xia, Qiang Cui, Xianming Deng, Xin Xu   +5 more
openalex   +2 more sources

Essential developmental processes in Physcomitrium patens require distinct levels of total activity provided by functionally redundant PpROP GTPases

New Phytologist, Volume 248, Issue 6, Page 2865-2890, December 2025.
Summary RHO (RAS homologous) GTPases regulate important cellular and developmental processes in most eukaryotes. Plant‐specific ROP (RHO of plants) GTPase families expanded and functionally diversified during the evolution of vascular plants, but contain few members in nonvascular extant relatives of early land plants.
Aude Le Bail, Benedikt Kost, Janina Nüssel, Tamara Isabeau Lolis, David Koch, Hildegard Voll, Sylwia Schulmeister, Alexander Kaier, Karin Ljung, Maria Ntefidou   +9 more
wiley   +1 more source

The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN. [PDF]

J Biol Chem, 2022
Nakano S, Nishikawa M, Kobayashi T, Harlin EW, Ito T, Sato K, Sugiyama T, Yamakawa H, Nagase T, Ueda H.   +9 more
europepmc   +1 more source

Long Non-Coding RNA LINC00355 Promotes the Development and Progression of Colorectal Cancer by Elevating Guanine Nucleotide Exchange Factor T Expression via RNA Binding Protein lin-28 Homolog A [PDF]

, 2020
Yuanyuan Wang, Bing Zhang, Ge Gao, Yinping Zhang, Qingxin Xia   +4 more
openalex   +1 more source

c‐Abl Kinase Targets Tight Junction Protein ZO‐2 in Regulation of Cell Migration and Morphology

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
c‐Abl binds and phosphorylates ZO‐2 directly at its C‐terminus and indirectly at the N‐terminus via JAK1. These phosphorylation events weaken cytoskeletal contractility, lower traction forces, and reduce cell migration, establishing ZO‐2 as a central mediator linking c‐Abl activity to changes in cell morphology and motility.
Doo Eun Choi, Bomi Gweon, Jacob Notbohm, Heejin Kim, Xue‐Song Liu, Jeffrey J. Fredberg   +5 more
wiley   +1 more source