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Expression of Rho Guanine Nucleotide Exchange Factor 39 (ARHGEF39) and Its Prognostic Significance in Hepatocellular Carcinoma. [PDF]
Med Sci Monit, 2019 Gao J, Jia WD.
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The guanine nucleotide-exchange factor, eIF-2B
Biochimie, 1994Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from inactive [eIF-2.GDP] complexes, thus allowing formation of the ...
N, Price, C, Proud
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Dbl family guanine nucleotide exchange factors
Trends in Biochemical Sciences, 2001The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction ...
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A Small Molecule-Regulated Guanine Nucleotide Exchange Factor
Journal of the American Chemical Society, 2009Selective, pharmacological agents are attractive tools for studying signal transduction because they allow rapid, reversible, and dose-dependent control over intracellular protein function. However, for many targets the identification of potent and selective small molecule agonists and antagonists is a formidable challenge.
Inna, Goreshnik, Dustin J, Maly
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Guanine nucleotide exchange factors: Activators of Ras superfamily proteins
Molecular Reproduction and Development, 1995AbstractMembers of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle between active GTP‐complexed and inactive GDP‐complexed states. Guanine nucleotide exchange factors (GEFs) stimulate formation of the GTP‐bound state, whereas GTPase activating proteins (GAPs) catalyze the formation of the GDP‐bound state.
A F, Overbeck +8 more
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Asef is a Cdc42-specific guanine nucleotide exchange factor
Biological Chemistry, 2007Asef is a member of the Dbl-family of guanine nucleotide exchange factors (GEFs) with a proposed specificity for the small GTPase Rac1. Here we investigated the specificity and regulation of Asef by measuring its GEF activity in vitro and observed hardly any activity towards Rac1, Rac2 and Rac3, or RhoA and TC10.
Gotthardt, K., Ahmadian, M.
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GrinchGEF—A novel Rho-specific guanine nucleotide exchange factor
Biochemical and Biophysical Research Communications, 2005RhoGTPases, which are activated by specific guanine nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. We identified a new RhoGEF (GrinchGEF) containing the typical Dbl homology domain, a putative WD40-like domain, and two predicted transmembrane helices.
Stefan, Winkler +3 more
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Large ARF guanine nucleotide exchange factors in membrane trafficking
Cellular and Molecular Life Sciences, 2008In eukaryotic cells membrane compartments are connected through cargo-selective vesicle trafficking mediating the exchange of components between different organelles. This exchange is essential to maintain their structural integrity and specific composition.
N, Anders, G, Jürgens
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Myelination by signaling through Arf guanine nucleotide exchange factor
Journal of NeurochemistryAbstract During myelination, large quantities of proteins are synthesized and transported from the endoplasmic reticulum (ER)‐trans‐Golgi network (TGN) to their appropriate locations within the intracellular region and/or plasma membrane.
Tomohiro Torii +2 more
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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Nature Reviews Molecular Cell Biology, 2005Channing J Der, John E Sondek
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