Results 11 to 20 of about 105,827 (294)

Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. [PDF]

PLoS ONE, 2012
Spatio-temporal activation of Rho GTPases is essential for their function in a variety of biological processes and is achieved in part by regulating the localization of their activators, the Rho guanine nucleotide exchange factors (RhoGEFs).
Natalia Mitin, Kent L Rossman, Channing J Der   +2 more
doaj   +3 more sources

Correction: The Guanine Nucleotide Exchange Factor RIC8 Regulates Conidial Germination through Gα Proteins in. [PDF]

PLoS ONE, 2013
Heterotrimeric G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crassa. We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and
Carla J. Eaton, Ilva E. Cabrera, Jacqueline A. Servin, Sara J. Wright, Murray P. Cox, Katherine A. Borkovich   +5 more
doaj   +14 more sources

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis

Nature Communications, 2022
Ph+ and Ph-like B-ALL remain poor prognosis leukemias. VAV3, a guanine nucleotide exchange factor, is activated and overexpressed in these leukemias. Here the authors reveal that leukemic VAV3 is predominantly nuclear.
R. C. Nayak, K. H. Chang, A. K. Singh, M. Kotliar, M. Desai, A. M. Wellendorf, M. Wunderlich, J. Bartram, B. Mizukawa, M. Cuadrado, P. Dexheimer, A. Barski, X. R. Bustelo, N. N. Nassar, J. A. Cancelas   +14 more
doaj   +1 more source

The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways. [PDF]

Exp Mol Med
Kim JA, Im S, Lim J, Hong JM, Ihn HJ, Bae JS, Kim JE, Bae YC, Park EK.   +8 more
europepmc   +3 more sources

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis

Cells, 2021
Exchange proteins directly activated by cAMP (EPAC1 and EPAC2) are one of the several families of cellular effectors of the prototypical second messenger cAMP.
Zhuofu Ni, Xiaodong Cheng
doaj   +1 more source

The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. [PDF]

PLoS ONE, 2010
Intersectin-1L is a member of the Dbl homology (DH) domain guanine nucleotide exchange factors (GEF) which control Rho-family GTPase signaling. Intersectin-1L is a GEF that is specific for Cdc42.
K Farid Ahmad, Wendell A Lim
doaj   +1 more source

GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

iScience, 2021
Summary: eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR).
Christopher J. Kershaw, Martin D. Jennings, Francesco Cortopassi, Margherita Guaita, Hawra Al-Ghafli, Graham D. Pavitt   +5 more
doaj   +1 more source

Guanine Nucleotide Exchange Factor

Definitions, 2020
Arora PD, Marignani PA, McCulloch CA. Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2. Am J Physiol Cell Physiol 295: C130–C137, 2008. First published April 23, 2008; doi:10.1152/ajpcell.00168.2008.—Collagen phagocytosis
P. Arora, P. A. Marignani, C. A. McCulloch   +2 more
semanticscholar   +1 more source

Targeting Rac and Cdc42 GEFs in Metastatic Cancer

Frontiers in Cell and Developmental Biology, 2020
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado, Julia Isabel Medina, Luis Velazquez, Suranganie Dharmawardhane   +3 more
doaj   +1 more source