Results 11 to 20 of about 93,566 (291)
Nature Communications, 2022 Ph+ and Ph-like B-ALL remain poor prognosis leukemias. VAV3, a guanine nucleotide exchange factor, is activated and overexpressed in these leukemias. Here the authors reveal that leukemic VAV3 is predominantly nuclear.
R. C. Nayak +14 more
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Frontiers in Cell and Developmental Biology, 2022 Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li +3 more
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The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. [PDF]
PLoS ONE, 2010 Intersectin-1L is a member of the Dbl homology (DH) domain guanine nucleotide exchange factors (GEF) which control Rho-family GTPase signaling. Intersectin-1L is a GEF that is specific for Cdc42.
K Farid Ahmad, Wendell A Lim
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Cells, 2021 Exchange proteins directly activated by cAMP (EPAC1 and EPAC2) are one of the several families of cellular effectors of the prototypical second messenger cAMP.
Zhuofu Ni, Xiaodong Cheng
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GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity
iScience, 2021 Summary: eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR).
Christopher J. Kershaw +5 more
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Role of ARHGEF3 as a GEF and mTORC2 Regulator
Frontiers in Cell and Developmental Biology, 2022 Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq +5 more
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Targeting Rac and Cdc42 GEFs in Metastatic Cancer
Frontiers in Cell and Developmental Biology, 2020 The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado +3 more
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Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation [PDF]
, 2012 Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the ...
Eva Greganova +5 more
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Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22. [PDF]
PLoS ONE, 2015 Legionella pneumophila, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery.
Young-Sik Sohn +9 more
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A disappearing act performed by magnesium: the nucleotide exchange mechanism of Ran GTPase by Quantum mechanics/Molecular mechanics studies [PDF]
, 2016 The Ran GTPase protein is a guanine nucleotide-binding protein (GNBP) with an acknowledged profile in cancer onset, progression and metastases. The complex mechanism adopted by GNBPs in exchanging GDP for GTP is an intriguing process and crucial for Ran ...
Huang, Meilan +3 more
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