Results 191 to 200 of about 41,746 (257)

Distinct Effects of Nonselective Rho‐Kinase Inhibitor Fasudil and Selective Rho‐Kinase 2 Inhibitor KD025 on Serotonin and Dopamine Release in the Nucleus Accumbens of Mice

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Fasudil perfusion in the NAc increased basal extracellular serotonin but not dopamine, and suppressed depolarization‐evoked release of both. In contrast, KD025 showed minimal effects on basal levels and selectively suppressed evoked serotonin release. ABSTRACT Recent studies have indicated that the Rho GTPase family and Rho‐kinases are associated with ...
Rinako Tanaka, Wenjun Zhu, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi, Kiyofumi Yamada   +8 more
wiley   +1 more source

Use of tandem‐affinity chromatography to incorporate nucleotide loading of small GTPases during their purification

Protein Science, Volume 35, Issue 6, June 2026.
Abstract A bottleneck for structure–function studies of closely related proteins is purification. Here, we built upon new affinity protein purification technology to develop a uniform and rapid tandem‐affinity purification protocol to generate significant quantities of pure GTPase proteins for use in structure–function studies. Our method relies on new
Rofiat Oladimeji, Chigozie Odo, Ethan Lewis, Gracie Reid, Christian W. Johnson   +4 more
wiley   +1 more source

Vav Guanine nucleotide exchange factors regulate atherosclerotic lesion development in mice. [PDF]

Arterioscler Thromb Vasc Biol, 2013
Rahaman SO, Li W, Silverstein RL.
europepmc   +1 more source

Rho Guanine Nucleotide Exchange Factor 2 [PDF]

, 2020
openaire   +1 more source

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Wheat's war against stripe rust: Integrating host immunity, genomics and breeding for durable resistance

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Wheat (Triticum aestivum L.), a foundation of global food security, faces persistent threats from stripe rust caused by Puccinia striiformis f. sp. tritici (Pst). The pathogen thrives in cool and humid environments and regularly causes epidemics that lead to severe yield losses.
Farkhandah Jan, Mukesh Rathore, Dinesh Kumar Saini, Ayushi Singh, Naeela Qureshi, Nikita Aggarwal, Mahpara Bashir, Mehnaz Shakeel, Vikas Gupta, Sundeep Kumar, Rajeev Kumar Varshney, Reyazul Rouf Mir   +11 more
wiley   +1 more source

Rho Guanine Nucleotide Exchange Factor 28 [PDF]

, 2020
openaire   +1 more source

Genetic diversity and population structure of jute mallow (Corchorus olitorius L.) global collection to guide conservation and breeding

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Understanding the genome‐wide diversity of jute mallow (Corchorus olitorius L.) is crucial for unlocking the potential of global genebank collections, enabling the discovery and use of traits that support climate resilience, improve nutrition, and increase productivity.
Abdul J. Shango, Emmanuel O. Omondi, Sognigbé N'Danikou, Dèdéou A. Tchokponhoué, M. Eric Schranz, Bodovololona Rabary, Mujuni Sospeter Kabululu, Thembinkosi Gumedze, Enoch G. Achigan‐Dako, Pavithravani Venkataramana, Mashamba L. Philipo, Maarten van Zonneveld   +11 more
wiley   +1 more source

Rho Guanine Nucleotide Exchange Factor 7 [PDF]

, 2020
openaire   +1 more source

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure‐Directed Missense Mutations in the Endogenous AGE‐1/Phosphatidylinositol 3‐Kinase Catalytic Subunit

Aging Cell, Volume 25, Issue 6, June 2026.
Structure‐guided missense mutations in the C. elegans AGE‐1/PI3Kinase catalytic subunit and its LET‐60/Ras‐binding interface reveal separable signaling outputs from the Ras‐bound PI3K complex. Enhanced canonical catalytic activity, conferred by a gain‐of‐function mutation modeled on oncogenic human p110⍺ PI3K variants, promotes aging, reproductive ...
You Wu, Tam Duong, Neal R. Rasmussen, Kent L. Rossman, David J. Reiner   +4 more
wiley   +1 more source