Results 191 to 200 of about 9,354,840 (235)

Research Progress on the ARHGEF Family in Cardiovascular Diseases. [PDF]

Cell Biochem Funct
Zhang H, Guo Q, Mugaka BP, Tai G, Xu M.
europepmc   +1 more source

Ion Channel-Rho GTPase Coupling in Human Odontogenesis: Integrative Structural and Network Dissection of TRIO and CACNA2D2 Variants From Familial Tooth Agenesis. [PDF]

Cureus
Nabbout F, Sabbagh J, El Hajj J, Ghassibe M.   +3 more
europepmc   +1 more source

ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB. [PDF]

J Biol Chem
Scott MK, Klynsoon GCT, Walsh EE, Suresh S, Nyvall HG, Burke JE.   +5 more
europepmc   +1 more source

A de novo Loss-of-function Variant in RAPGEF6 Supports its Role in Neuropsychiatric Disorders. [PDF]

J Mol Neurosci
Treccarichi S, Vinci M, Figura MG, Musumeci A, Virgillito M, Papa C, Chiavetta V, Brancato D, Bruno F, Federico C, Simo J, La Piana R, Saccone S, Calì F.   +13 more
europepmc   +1 more source

Non-canonical and constitutive activation of small GTPases: more than an exception to the rule? [PDF]

Biochem J
Kiers J, Hordijk PL.
europepmc   +1 more source

Cortisol-Responsive regulation of RASGRP1 in lymphoblastoid cells from individuals with bipolar disorder. [PDF]

BMC Res Notes
Sarsah SK, Murray MN.
europepmc   +1 more source

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Dbl family guanine nucleotide exchange factors

Trends in Biochemical Sciences, 2001
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction ...
Yi Zheng
openaire   +4 more sources

The guanine nucleotide-exchange factor, eIF-2B

Biochimie, 1994
Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from inactive [eIF-2.GDP] complexes, thus allowing formation of the ...
N, Price, C, Proud
openaire   +2 more sources

Asef is a Cdc42-specific guanine nucleotide exchange factor

Biological Chemistry, 2007
Asef is a member of the Dbl-family of guanine nucleotide exchange factors (GEFs) with a proposed specificity for the small GTPase Rac1. Here we investigated the specificity and regulation of Asef by measuring its GEF activity in vitro and observed hardly any activity towards Rac1, Rac2 and Rac3, or RhoA and TC10.
Gotthardt, K., Ahmadian, M.
openaire   +3 more sources

A Small Molecule-Regulated Guanine Nucleotide Exchange Factor

Journal of the American Chemical Society, 2009
Selective, pharmacological agents are attractive tools for studying signal transduction because they allow rapid, reversible, and dose-dependent control over intracellular protein function. However, for many targets the identification of potent and selective small molecule agonists and antagonists is a formidable challenge.
Inna, Goreshnik, Dustin J, Maly
openaire   +2 more sources