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The RasGrf family of mammalian guanine nucleotide exchange factors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011
RasGrf1 and RasGrf2 are highly homologous mammalian guanine nucleotide exchange factors which are able to activate specific Ras or Rho GTPases. The RasGrf genes are preferentially expressed in the central nervous system, although specific expression of either locus may also occur elsewhere.
Fernández Medarde, Alberto   +1 more
openaire   +4 more sources

Mechanism of activation of guanine nucleotide exchange factor by insulin

Endocrine, 1995
Insulin increases activity of the guanine nucleotide exchange factor (GEF) in Rat-1 fibroblasts transfected with human insulin receptors (HIRc cells), thereby promoting formation of the active form of p21Ras (p21Ras•GTP). In order to identify the upstream molecules mediating this aspect of insulin action, we selectively removed some of these molecules ...
J, Langlois   +5 more
openaire   +2 more sources

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

Journal of Cell Biology, 1997
Onno Kranenburg   +2 more
exaly  

Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction

Acta Crystallographica Section D: Biological Crystallography, 2013
Takashi Ueda, Ryuichi Kato
exaly  

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