Results 201 to 210 of about 41,746 (257)

Insights into the biological functions of Dock family guanine nucleotide exchange factors. [PDF]

Genes Dev, 2014
Laurin M, Côté JF.
europepmc   +1 more source

Decoding the Oncogenic Role of GNG10 in Colorectal Cancer: A Non‐Canonical Wnt Pathway–Driven Mechanism

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Guanine nucleotide‐binding protein gamma 10 (GNG10) is implicated in various biological processes, yet its specific oncogenic role in colorectal cancer (CRC) remains poorly defined. This study aimed to elucidate the expression patterns, biological functions, and underlying mechanisms of GNG10 in CRC progression.
Xitao Zhang, Yuting Tang, Xuexiao Li, Ou Li, Yaoqian Liu, Jianping He, Tianlai Liu   +6 more
wiley   +1 more source

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
wiley   +1 more source

Tissue‐Specific Plasticity of DNA Methylation Across Intertidal Microhabitats in Juvenile Mussels (Mytilus californianus)

Molecular Ecology, Volume 35, Issue 11, June 2026.
ABSTRACT Epigenetic modifications to DNA are proposed to underpin plastic responses to environmental change, and the manner in which DNA methylation contributes to plasticity likely differs among tissues. However, few studies have investigated tissue‐specific DNA methylation responses to ecologically relevant environmental stressors in natural settings.
Qiting Cai, Samuel N. Bogan, Richelle L. Tanner, Joanna L. Kelley, W. Wesley Dowd   +4 more
wiley   +1 more source

Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.

J Cell Sci, 2018
Tay YD, Leda M, Goryachev AB, Sawin KE.
europepmc   +1 more source

Rho Guanine Nucleotide Exchange Factor 10 [PDF]

, 2020
openaire   +1 more source

The DENN Protein SMD1 Forms a Signalling Hub With Rab GTPase YPT1 to Regulate Diverse Biological Processes in Phytopathogenic Fungi and Serves as a HIGS Target for Crop Protection

Molecular Plant Pathology, Volume 27, Issue 6, June 2026.
The DENN domain‐containing protein SsSMD1 is highly conserved across phytopathogenic fungi. Functioning as a putative GEF for RAS GTPase SsYPT1, SsSMD1 orchestrates its activation to regulate cell wall integrity, sclerotia development, and virulence in Sclerotinia sclerotiorum.
Cheng Zhang, Lin Li, Sunhong Liu, Yan Xu, Xin Li, Yuelin Zhang   +5 more
wiley   +1 more source

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, Volume 604, Issue 11, Page 4387-4404, 1 June 2026.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Rho Guanine Nucleotide Exchange Factor 5 [PDF]

, 2020
openaire   +1 more source

Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes. [PDF]

Mol Biol Cell, 2015
Bean BD, Davey M, Snider J, Jessulat M, Deineko V, Tinney M, Stagljar I, Babu M, Conibear E.   +8 more
europepmc   +1 more source