Results 201 to 210 of about 83,277 (241)

Asef is a Cdc42-specific guanine nucleotide exchange factor

Biological Chemistry, 2007
Asef is a member of the Dbl-family of guanine nucleotide exchange factors (GEFs) with a proposed specificity for the small GTPase Rac1. Here we investigated the specificity and regulation of Asef by measuring its GEF activity in vitro and observed hardly any activity towards Rac1, Rac2 and Rac3, or RhoA and TC10.
Gotthardt, K., Ahmadian, M.
openaire   +3 more sources

GrinchGEF—A novel Rho-specific guanine nucleotide exchange factor

Biochemical and Biophysical Research Communications, 2005
RhoGTPases, which are activated by specific guanine nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. We identified a new RhoGEF (GrinchGEF) containing the typical Dbl homology domain, a putative WD40-like domain, and two predicted transmembrane helices.
Stefan, Winkler, Marion, Mohl, Thomas, Wieland, Susanne, Lutz   +3 more
openaire   +2 more sources

Large ARF guanine nucleotide exchange factors in membrane trafficking

Cellular and Molecular Life Sciences, 2008
In eukaryotic cells membrane compartments are connected through cargo-selective vesicle trafficking mediating the exchange of components between different organelles. This exchange is essential to maintain their structural integrity and specific composition.
N, Anders, G, Jürgens
openaire   +2 more sources

Myelination by signaling through Arf guanine nucleotide exchange factor

Journal of Neurochemistry
Abstract During myelination, large quantities of proteins are synthesized and transported from the endoplasmic reticulum (ER)‐trans‐Golgi network (TGN) to their appropriate locations within the intracellular region and/or plasma membrane.
Tomohiro Torii, Yuki Miyamoto, Junji Yamauchi   +2 more
openaire   +2 more sources

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Nature Reviews Molecular Cell Biology, 2005
Channing J Der, John E Sondek
exaly  

Guanine Nucleotide Exchange Factors (GEFs)

2006
openaire   +2 more sources

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

Nature, 2000
John E Sondek
exaly  

Guanine Nucleotide Exchange Factor

2012
openaire   +1 more source

EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

Cell, 2001
Michael Z Lin, Soline Estrach, Jeffrey L Goldberg   +2 more
exaly  

Guanine Nucleotide Exchange Factors

2011
openaire   +1 more source