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The RasGrf family of mammalian guanine nucleotide exchange factors
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011RasGrf1 and RasGrf2 are highly homologous mammalian guanine nucleotide exchange factors which are able to activate specific Ras or Rho GTPases. The RasGrf genes are preferentially expressed in the central nervous system, although specific expression of either locus may also occur elsewhere.
Fernández Medarde, Alberto +1 more
openaire +4 more sources
Mechanism of activation of guanine nucleotide exchange factor by insulin
Endocrine, 1995Insulin increases activity of the guanine nucleotide exchange factor (GEF) in Rat-1 fibroblasts transfected with human insulin receptors (HIRc cells), thereby promoting formation of the active form of p21Ras (p21Ras•GTP). In order to identify the upstream molecules mediating this aspect of insulin action, we selectively removed some of these molecules ...
J, Langlois +5 more
openaire +2 more sources
Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1
Small GTPases, 2021Michael F Olson
exaly

