Nuclear Functions of the Arf Guanine Nucleotide Exchange Factor BRAG2 [PDF]
, 2007 Jillian L. Dunphy +2 more
openalex +1 more source
Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors
Medicinal Research Reviews, Volume 46, Issue 2, Page 445-474, March 2026.ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara +3 more
wiley +1 more source
RHO OF PLANTS signalling and the activating ROP GUANINE NUCLEOTIDE EXCHANGE FACTORS: specificity in cellular signal transduction in plants. [PDF]
J Exp BotDenninger P.
europepmc +1 more source
RalGEF2, a Pleckstrin Homology Domain Containing Guanine Nucleotide Exchange Factor for Ral [PDF]
, 2000 Kim M.T. de Bruyn +7 more
openalex +1 more source
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
Endogenous expression and protein kinase A‐dependent phosphorylation of the guanine nucleotide exchange factor Ras‐GRF1 in human embryonic kidney 293 cells [PDF]
, 2005 Jens Henrik Norum +3 more
openalex +1 more source
Induced opening of conformational switch I in GTP‐bound Ran GTPase
Protein Science, Volume 35, Issue 3, March 2026.Abstract Ran is a small GTPase that regulates nucleocytoplasmic transport by cycling between an inactive GDP‐bound and active GTP‐bound state. Structurally, Ran consists of a globular G‐domain and a C‐terminal region that includes a C‐terminal helix. The switch I and II regions of the G‐domain undergo major conformational changes upon GTP hydrolysis ...
Janka Czigleczki +2 more
wiley +1 more source
The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes
Protein Science, Volume 35, Issue 3, March 2026.Abstract Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or Rac1 is the actual substrate inactivated by RacGAP1 ...
Pavlina Dubois +5 more
wiley +1 more source