Results 161 to 170 of about 103,400 (342)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

First Report of Homozygous COL7A1 c.5756delG Mutation Causing Recessive Dystrophic Epidermolysis Bullosa in a Non‐Consanguineous Japanese Family

JEADV Clinical Practice, EarlyView.
ABSTRACT Severe recessive dystrophic epidermolysis bullosa (RDEB) is usually caused by biallelic loss‐of‐function mutations in COL7A1. While the c.5756delG variant has been previously reported in heterozygous form, its clinical impact in homozygosity has not been described.
Nozomi Kohama, Sayaka Yamaguchi, Teruki Yanagi, Yumi Akamine, Kimiko Nonaka, Daisuke Utsumi, Kenzo Takahashi   +6 more
wiley   +1 more source

High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription. [PDF]

Curr Genet, 2019
Hesketh A, Oliver SG.
europepmc   +1 more source

Guanine Nucleotide Exchange Factor [PDF]

, 2020
openaire   +1 more source

Bombesin, neuromedin B and neuromedin C interact with a common rat pancreatic phosphoinositide-coupled receptor, but are differentially regulated by guanine nucleotides [PDF]

, 1991
Mahendran Sekar, Naomi Uemura, D.H. Coy, Basil I. Hirschowitz, Kenneth E.J. Dickinson   +4 more
openalex   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism.

, 1991
Stephen M. Strittmatter, Dario Valenzuela, Yuta Sudo, Maurine E. Linder, Mark C. Fishman   +4 more
openalex   +1 more source

Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility [PDF]

, 2015
Kyungmin Lee, Yuki Kobayashi, Hyunhyo Seo, Ji‐Hye Kwak, Akira Masuda, Chae‐Seok Lim, Hye‐Ryeon Lee, SukJae Joshua Kang, Pojeong Park, Su-Eon Sim, Naomi Kogo, Hiroaki Kawasaki, Bong‐Kiun Kaang, Shigeyoshi Itohara   +13 more
openalex   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Vps9 assisted guanine nucleotide exchange intermediates of Rab5 [PDF]

, 2008
Kunio Ihara, Tamami Uejima, Teik Beng Goh, Emi Ito, Miki Sunada, Tetsufumi Ueda, Akihiko Nakano, Soichi Wakatsuki   +7 more
openalex   +1 more source