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pH-Dependent Perturbation of Ras−Guanine Nucleotide Interactions and Ras Guanine Nucleotide Exchange
Biochemistry, 2004p21Ras (Ras) proteins cycle between active GTP-bound and inactive GDP-bound states to mediate signal transduction pathways that promote cell growth, differentiation, and apoptosis. To better understand how cellular regulatory factors, such as guanine nucleotide exchange factors (GEFs) and nitric oxide (NO), modulate Ras-guanine nucleotide binding ...
Jongyun, Heo +2 more
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Fibres of Guanine Nucleosides and Nucleotides
Nature, 1963IT has been shown by Gellert, Lipsett and Davies1 that guanylic acid will form a gel under certain pH conditions and they were able to draw fibres from gels of the disodium salt of 3′-guanylic acid and of the free acid, 5′-guanosine monophosphate. From X-ray diffraction studies of these fibres the foregoing workers concluded that they consisted of a ...
J, IBALL, C H, MORGAN, H R, WILSON
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European Journal of Biochemistry, 1994
In order to study whether phosphate transfer reactions are involved in the binding of guanine nucleotide triphosphates to guanine‐nucleotide‐binding regulatory proteins, binding of the GTP analogues, guanosine 5′‐[γ‐thio]triphosphate, GTP[S], and guanosine 5′‐[β,γ‐imino]triphosphate, p[NH]ppG, and the regulation of binding by the formly‐peptide ...
S, Kaldenberg-Stasch +4 more
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In order to study whether phosphate transfer reactions are involved in the binding of guanine nucleotide triphosphates to guanine‐nucleotide‐binding regulatory proteins, binding of the GTP analogues, guanosine 5′‐[γ‐thio]triphosphate, GTP[S], and guanosine 5′‐[β,γ‐imino]triphosphate, p[NH]ppG, and the regulation of binding by the formly‐peptide ...
S, Kaldenberg-Stasch +4 more
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Guanine Nucleotide Dissociation Stimulators
1993Small Ras-like GTPases function as bipolar molecular switches to control a variety of cellular processes (Bourne et al. 1991a,b). The switches cycle between GTP- and GDP-bound states. Evidence from oncogenic mutants of Ras identified the GTP-bound form as the active state, a conclusion that has been substantiated by the effects of dominant negative ...
I. G. Macara, E. S. Burstein
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Dbl family guanine nucleotide exchange factors
Trends in Biochemical Sciences, 2001The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction ...
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Guanine-Nucleotide-Binding Regulatory Proteins
1985Studies of the hormone-sensitive adenylate cyclase complex and of mechanisms of transduction of visual information have led to the discovery of a family of guanine-nucleotide-binding regulatory proteins. This family is now known to include at least four highly homologous members.
Alfred G. Gilman +3 more
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