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The Guanine Nucleotide-Binding Switch in Three Dimensions

Science, 2001
Guanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states.
I R, Vetter, A, Wittinghofer
openaire   +2 more sources

Transducin: A Signaling Switch Regulated by Guanine Nucleotides

1989
Publisher Summary This chapter discusses the information obtained from the biochemical studies of transducin and attempts to integrate this information with the proposed structure of the GTP binding α subunit of transducin (T α ). One of the best-studied biological processes regulated by G proteins is the visual excitation of vertebrate ...
Y K, Ho   +3 more
openaire   +2 more sources

Dbl family guanine nucleotide exchange factors

Trends in Biochemical Sciences, 2001
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction ...
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Guanine nucleotides in protein synthesis

Archives of Biochemistry and Biophysics, 1974
Ernest Hamel, Michael Cashel
openaire   +1 more source

Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2021
Núria Sanchez Puig
exaly  

Guanine nucleotides decrease the affinity of substance P binding to its receptor

European Journal of Pharmacology, 1990
Arti Patel, Norman D Boyd, N D Boyd
exaly  

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