Results 261 to 270 of about 150,931 (301)
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures
Biochemical and Molecular Medicine, 1995The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
E, Zoref-Shani +4 more
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures
Journal of Neurochemistry, 1992Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
S, Brosh +3 more
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Biochemistry, 1990
Transducin (Gt) is a member of a family of receptor-coupled signal-transducing guanine nucleotide (GN) binding proteins (G-proteins). Light-activated rhodopsin is known to catalyze GN exchange on Gt, resulting in the formation of the active state of the Gt alpha-GTP complex.
A B, Fawzi, J K, Northup
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Transducin (Gt) is a member of a family of receptor-coupled signal-transducing guanine nucleotide (GN) binding proteins (G-proteins). Light-activated rhodopsin is known to catalyze GN exchange on Gt, resulting in the formation of the active state of the Gt alpha-GTP complex.
A B, Fawzi, J K, Northup
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Guanine nucleotides and their significance in biochemical processes
The American Journal of Clinical Nutrition, 1974Various developing aspects of the involvement of guanine nucleotides in intermediary metabolism are reviewed. Particular stress is laid on the importance of these nucleotides as potential regulators, e.g., the role of GTP in the stimulation of the adenylate cyclase system of hormones such as epinephrine and glucagon, of cyclic 3'.S'-GMP as a mediator ...
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Vibrations and stability of nucleotides: guanine
SPIE Proceedings, 2005In this contribution we report on a study of conformational changes of guanine in the temperature range from 300 to 600 K. We have used a new molecular dynamics with charges at bonds and have studied time dependence of interatomic distances for the first and second neighbors at these temperatures.
Sergey A. Mendeleev +2 more
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Guanine Nucleotide Dissociation Stimulators
1993Small Ras-like GTPases function as bipolar molecular switches to control a variety of cellular processes (Bourne et al. 1991a,b). The switches cycle between GTP- and GDP-bound states. Evidence from oncogenic mutants of Ras identified the GTP-bound form as the active state, a conclusion that has been substantiated by the effects of dominant negative ...
I. G. Macara, E. S. Burstein
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European Journal of Biochemistry, 1994
In order to study whether phosphate transfer reactions are involved in the binding of guanine nucleotide triphosphates to guanine‐nucleotide‐binding regulatory proteins, binding of the GTP analogues, guanosine 5′‐[γ‐thio]triphosphate, GTP[S], and guanosine 5′‐[β,γ‐imino]triphosphate, p[NH]ppG, and the regulation of binding by the formly‐peptide ...
S, Kaldenberg-Stasch +4 more
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In order to study whether phosphate transfer reactions are involved in the binding of guanine nucleotide triphosphates to guanine‐nucleotide‐binding regulatory proteins, binding of the GTP analogues, guanosine 5′‐[γ‐thio]triphosphate, GTP[S], and guanosine 5′‐[β,γ‐imino]triphosphate, p[NH]ppG, and the regulation of binding by the formly‐peptide ...
S, Kaldenberg-Stasch +4 more
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A guanine nucleotide-binding protein in human astrocytoma
Neurological Research, 1990We compared, by immunoblotting and immunohistochemical staining, the distribution of the alpha subunit of Go in human normal brain tissue with that in human brain tumours of neuroectodermal origin. The ten tumour samples included seven high-grade astrocytomas (grades III and IV) and three low-grade astrocytomas (grade II).
K, Takenaka +7 more
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The guanine nucleotide-exchange factor, eIF-2B
Biochimie, 1994Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from inactive [eIF-2.GDP] complexes, thus allowing formation of the ...
N, Price, C, Proud
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Effect of guanine nucleotides on the hydrophobic interaction of tubulin
Biochemistry, 1990The influence of guanine nucleotides on the binding of tubulin to hydrophobic components is investigated. Tubulin binds to a hydrophobic phenyl-Sepharose gel in a reversible, nucleotide-dependent way. Assembly-competent tubulin is released with ion-free water as eluent. It contains one guanosine triphosphate per dimer.
I, Hanssens, J, Baert, F, Van Cauwelaert
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