Results 321 to 330 of about 99,476 (367)
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures
Biochemical and Molecular Medicine, 1991The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
Esther Zoref-Shani +4 more
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Guanine Nucleotide Dissociation Stimulators [PDF]
, 1993 Small Ras-like GTPases function as bipolar molecular switches to control a variety of cellular processes (Bourne et al. 1991a,b). The switches cycle between GTP- and GDP-bound states. Evidence from oncogenic mutants of Ras identified the GTP-bound form as the active state, a conclusion that has been substantiated by the effects of dominant negative ...
E. S. Burstein, I. G. Macara
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Guanine nucleotides are present in human CSF
NeuroReport, 1997Several studies have shown that experimentally added guanine nucleotides (GN) may extracellularly modulate the glutamatergic system. However, there is no previous report of the extracellular occurrence of GN in the CNS. This study used HPLC to investigate the presence of GN in cerebrospinal fluid (CSF) samples of 26 patients.
F João P.j. Silveira +5 more
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Regulation of phosphoinositide breakdown by guanine nucleotides
Life Sciences, 1986Phosphoinositide hydrolysis is coupled to receptor systems involved in the elevation of cytosolic Ca2+ and activation of protein kinase C. In cell-free systems, guanine nucleotides are required to transduce the effects of receptor activation to phosphoinositide breakdown.
Irene Litosch, John N. Fain
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Inhibition of neutrophil migration by guanine nucleotides
Agents and Actions, 1991Guanine nucleotides have, besides an activating effect on exocytosis and respiratory burst in permeabilized neutrophils, a modulating effect on some functions in intact neutrophils. We investigated the effect of guanine nucleotides on fMet-Leu-Phe-induced migration of rabbit neutrophils using the Boyden chamber technique. GTP gave a moderate inhibition
B. M. De Koster +3 more
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Vibrations and stability of nucleotides: guanine
SPIE Proceedings, 2005In this contribution we report on a study of conformational changes of guanine in the temperature range from 300 to 600 K. We have used a new molecular dynamics with charges at bonds and have studied time dependence of interatomic distances for the first and second neighbors at these temperatures.
Maria A. Vorobyeva +2 more
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Biochemistry, 1990
Transducin (Gt) is a member of a family of receptor-coupled signal-transducing guanine nucleotide (GN) binding proteins (G-proteins). Light-activated rhodopsin is known to catalyze GN exchange on Gt, resulting in the formation of the active state of the Gt alpha-GTP complex.
John K. Northup, Ahmad B. Fawzi
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Transducin (Gt) is a member of a family of receptor-coupled signal-transducing guanine nucleotide (GN) binding proteins (G-proteins). Light-activated rhodopsin is known to catalyze GN exchange on Gt, resulting in the formation of the active state of the Gt alpha-GTP complex.
John K. Northup, Ahmad B. Fawzi
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures
Journal of Neurochemistry, 1992Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
S. Brosh +3 more
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Guanine nucleotides and their significance in biochemical processes
The American Journal of Clinical Nutrition, 1974Various developing aspects of the involvement of guanine nucleotides in intermediary metabolism are reviewed. Particular stress is laid on the importance of these nucleotides as potential regulators, e.g., the role of GTP in the stimulation of the adenylate cyclase system of hormones such as epinephrine and glucagon, of cyclic 3'.S'-GMP as a mediator ...
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A guanine nucleotide-binding protein in human astrocytoma
Neurological Research, 1990We compared, by immunoblotting and immunohistochemical staining, the distribution of the alpha subunit of Go in human normal brain tissue with that in human brain tumours of neuroectodermal origin. The ten tumour samples included seven high-grade astrocytomas (grades III and IV) and three low-grade astrocytomas (grade II).
Takashi Ando +7 more
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