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Effect of guanine nucleotides on the hydrophobic interaction of tubulin
Biochemistry, 1990The influence of guanine nucleotides on the binding of tubulin to hydrophobic components is investigated. Tubulin binds to a hydrophobic phenyl-Sepharose gel in a reversible, nucleotide-dependent way. Assembly-competent tubulin is released with ion-free water as eluent. It contains one guanosine triphosphate per dimer.
Van Cauwelaert F +2 more
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The guanine nucleotide-exchange factor, eIF-2B
Biochimie, 1994Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from inactive [eIF-2.GDP] complexes, thus allowing formation of the ...
Christopher G. Proud, Nigel T. Price
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Effects of guanine nucleotides on cns neuropeptide receptors
Journal of Supramolecular Structure and Cellular Biochemistry, 1981AbstractThe effect of nucleotides on central nervous system neuropeptide receptor binding was investigated. The guanine nucleotides, guanosine‐5′‐triphosphate and guanylyl‐5′‐imidodiphosphate, significantly inhibited the binding of radiolabeled vasoactive intestinal polypeptide but not that of [Tyr4]bombesin to rat brain membranes.
Candace B. Pert +2 more
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Receptor‐stimulated guanine‐nucleotide‐triphosphate binding to guanine‐nucleotide‐binding regulatory proteins [PDF]
European Journal of Biochemistry, 1994 In order to study whether phosphate transfer reactions are involved in the binding of guanine nucleotide triphosphates to guanine‐nucleotide‐binding regulatory proteins, binding of the GTP analogues, guanosine 5′‐[γ‐thio]triphosphate, GTP[S], and guanosine 5′‐[β,γ‐imino]triphosphate, p[NH]ppG, and the regulation of binding by the formly‐peptide ...
Thomas Wieland +4 more
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Enzymatic analysis of guanine nucleotides in tissues and cells
Analytical Biochemistry, 1978GTP and GDP concentrations can be determined by a simple and specific spectrophotometric assay that uses commercially available enzymes. The conversion of GTP to GDP catalyzed by nucleosidediphosphate kinase in the presence of ADP enables the subsequent use of guanylate kinase which is coupled with hexokinase and glucose-6-phosphate dehydrogenase as ...
Werner A. Kaiser, Dietrich Keppler
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Guanine-Nucleotide-Binding Regulatory Proteins
1985Studies of the hormone-sensitive adenylate cyclase complex and of mechanisms of transduction of visual information have led to the discovery of a family of guanine-nucleotide-binding regulatory proteins. This family is now known to include at least four highly homologous members.
M D Smigel +3 more
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The Guanine Nucleotide-Binding Switch in Three Dimensions
Science, 2001Guanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states.
Ingrid R. Vetter, Alfred Wittinghofer
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Transducin: A Signaling Switch Regulated by Guanine Nucleotides
1989Publisher Summary This chapter discusses the information obtained from the biochemical studies of transducin and attempts to integrate this information with the proposed structure of the GTP binding α subunit of transducin (T α ). One of the best-studied biological processes regulated by G proteins is the visual excitation of vertebrate ...
Vijay N. Hingorani +3 more
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Effect of guanine nucleotides on striatal dopamine receptors
Nature, 1978GUANINE NUCLEOTIDES have been shown to regulate the sensitivity of adenylate cyclase to hormones in several systems1–5, including the dopamine-sensitive adenylate cyclase in the caudate nucleus2,4. It has also been reported that in the presence of GTP the affinities of glucagon receptors6, β-adrenergic receptors7,8, prostaglandin E1 receptors9 and ...
Nancy R. Zahniser, Perry B. Molinoff
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A function of huntingtin in guanine nucleotide exchange on Rab11
NeuroReport, 2008Huntingtin is ubiquitously expressed and enriched in the brain. Deletion of the huntingtin gene in mice is lethal during early embryonic development. The function of huntingtin is, however, not clear. Here, we report that huntingtin is important for the function of Rab11, a critical GTPase in regulating membrane traffic from recycling endosomes to the ...
Marian DiFiglia +11 more
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