Results 111 to 120 of about 238,540 (308)
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Dissociation of guanosine 5′‐[γ‐thio]triphosphate from guanine‐nucleotide‐binding regulatory proteins in native cardiac membranes [PDF]
, 1992 Gerhard Hilf +3 more
openalex +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
The Senegalese Sole Mx gene promoter contains a variable microsatellite region involved in the transcriptional [PDF]
, 2015 Interferons (IFNs) play a key role against viral infections by stimulating the expression of IFN stimulated genes, such as Mx. The transcriptional regulation of these genes in fish are poorly understood.
Alonso-Sanchez, Maria del Carmen +4 more
core
Guanine-Based Purines as an Innovative Target to Treat Major Depressive Disorder
Frontiers in Pharmacology, 2021 Roberto F. Almeida +7 more
doaj +1 more source
Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics
Advanced Science, EarlyView.The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu +4 more
wiley +1 more source
Advanced Science, EarlyView.Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen +9 more
wiley +1 more source
Electrochemical and Spectroscopic Studies of Interactions of Mn(III) Complexes with Nucleic Bases and Nucleosides [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1995 The complexes of Mn(OAc)3 and/or Mn(acac)3 with nucleic bases and nucleosides (adenine, guanine, xanthine, adenosine and guanosine) have been synthesized in nonaqueous solution.
Davar Mohammadi Boghai +2 more
doaj