Chemistry – A European Journal, EarlyView.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
Characterisation of a Binary Transition Metal Complex of a 3ʹ,5ʹ-Cyclic Nucleotide [1]. Preparation and Structure of a Nickel(II) Complex of Guanosine 3ʹ,5ʹ-Cyclic Monophosphate [PDF]
, 1982 William S. Sheldrick
openalex +1 more source
Cytoskeleton, EarlyView.ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen +2 more
wiley +1 more source
Electrochemical and Spectroscopic Studies of Interactions of Mn(III) Complexes with Nucleic Bases and Nucleosides [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1995 The complexes of Mn(OAc)3 and/or Mn(acac)3 with nucleic bases and nucleosides (adenine, guanine, xanthine, adenosine and guanosine) have been synthesized in nonaqueous solution.
Davar Mohammadi Boghai +2 more
doaj
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
Front Cover: Sustainability and Chaos in the Abiotic Polymerization of 3′,5′ Cyclic Guanosine Monophosphate: The Role of Aggregation (ChemSystemsChem 1/2021) [PDF]
, 2020 Giovanna Costanzo +9 more
openalex +1 more source
Guanosine diphosphate glucose and guanosine diphosphate fructose from Eremothecium ashbyii [PDF]
Biochemical Journal, 1959 H G, PONTIS, A L, JAMES, J, BADDILEY
openaire +3 more sources
Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?
Clinical Pharmacology &Therapeutics, EarlyView.Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu +5 more
wiley +1 more source
Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment
Cell Death and DiseaseGlioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12–15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity ...
Simona D’Aprile +17 more
doaj +1 more source