Results 11 to 20 of about 194,604 (252)

Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model

Frontiers in Psychiatry, 2021
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness.
Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Eduardo R. Zimmer, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza   +17 more
doaj   +1 more source

Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
doaj   +1 more source

Guanosine Prevents Spatial Memory Impairment and Hippocampal Damage Following Amyloid-β_1–42 Administration in Mice

Metabolites, 2022
Alzheimer’s disease (AD) is a progressive neurodegenerative illness responsible for cognitive impairment and dementia. Accumulation of amyloid-beta (Aβ) peptides in neurons and synapses causes cell metabolism to unbalance, and the production of reactive ...
Victor Coelho, Luisa Bandeira Binder, Naiani Ferreira Marques, Leandra Celso Constantino, Gianni Mancini, Carla Inês Tasca   +5 more
doaj   +1 more source

SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]

, 2020
Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F, Jones-Carson, Jessica, Kant, Sashi, Kim, Ju-Sim, Liu, Lin, McClelland, Michael, Porwollik, Steffen, Till, James K, Vazquez-Torres, Andres   +8 more
core   +1 more source

Smartphone-Based Chemiluminescence Glucose Biosensor Employing a Peroxidase-Mimicking, Guanosine-Based Self-Assembled Hydrogel

Biosensors, 2023
Chemiluminescence is widely used for hydrogen peroxide detection, mainly exploiting the highly sensitive peroxidase-luminol-H2O2 system. Hydrogen peroxide plays an important role in several physiological and pathological processes and is produced by ...
Donato Calabria, Andrea Pace, Elisa Lazzarini, Ilaria Trozzi, Martina Zangheri, Massimo Guardigli, Silvia Pieraccini, Stefano Masiero, Mara Mirasoli   +8 more
doaj   +1 more source

Neuromodulatory Effects of Guanine-Based Purines in Health and Disease

Frontiers in Cellular Neuroscience, 2018
The function of guanine-based purines (GBPs) is mostly attributed to the intracellular modulation of heteromeric and monomeric G proteins. However, extracellular effects of guanine derivatives have also been recognized.
Carla I. Tasca, Carla I. Tasca, Débora Lanznaster, Débora Lanznaster, Karen A. Oliveira, Karen A. Oliveira, Victor Fernández-Dueñas, Victor Fernández-Dueñas, Francisco Ciruela, Francisco Ciruela   +9 more
doaj   +1 more source

Advanced Raman spectroscopy detection of oxidative damage in nucleic acid bases: probing chemical changes and intermolecular interactions in guanosine at ultralow concentration [PDF]

, 2021
DNA/RNA synthesis precursors are especially vulnerable to damage induced by reactive oxygen species occurring following oxidative stress. Guanosine triphosphates are the prevalent oxidized nucleosites, which can be misincorporated during replication, leading to mutations and cell death. Here, we present a novel method based on micro-Raman spectroscopy,
arxiv   +1 more source

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Journal of Clinical Investigation, 1989
Endothelium-derived relaxing factor has been recently identified as nitric oxide. The purpose of this study was to determine if vasodilator drugs that generate nitric oxide inhibit vascular smooth muscle mitogenesis and proliferation in culture.
U. Garg, A. Hassid
semanticscholar   +1 more source

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz, BD Gill, C Crawford, Claire M. Peppiatt-Wildman, DR Ferguson, DR Schneider, EM Schwiebert, EW Inscho, EW Inscho, FQ Yang, G Burnstock, G Burnstock, G Burnstock, G Manfredi, G Xu, HA Neufeld, HA Praetorius, HA Praetorius, Hardyal S. Gill, HM Liebich, I Kugelgen von, I Kugelgen von, J Czarnecka, James Malone-Lee, JC Mathies, Jennifer C. Jacoby, JM Buescher, JO Svensson, JR Gever, K Sugaya, Kevin M. G. Taylor, KH Schram, KR Kim, LA Birder, LC Rump, LD Todorov, M Cichna, M Katayama, MA Bailey, N Ozer, N Yamaoka, NS Zur, P Bodin, P Vinas, PD Wilson, R Corriden, RC Calvert, Rebecca E. Birch, RL Cordell, S Tatur, S Wiener, SA Levesque, Scott S. P. Wildman, Toby S. Scott-Ward, V Jankowski, V Kumar, W Yu, Y Cheng, Y Sun, Y Sun, Y Zheng   +60 more
core   +2 more sources

Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments

Journal of Cell Biology, 2018
We used electron tomography to examine microtubules (MTs) growing from pure tubulin in vitro as well as two classes of MTs growing in cells from six species.
J. McIntosh, E. O'Toole, G. Morgan, Jotham Austin, E. Ulyanov, F. Ataullakhanov, F. Ataullakhanov, N. Gudimchuk, N. Gudimchuk   +8 more
semanticscholar   +1 more source