Results 11 to 20 of about 225,684 (400)
On the epigenetic role of guanosine oxidation
Redox Biology, 2019 Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common reactions in biological systems and often part of regulatory circuits rather than accidental events.
M. Giorgio +4 more
semanticscholar +8 more sources
Frontiers in Pharmacology, 2018 The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells.
T. Pietrangelo +9 more
semanticscholar +3 more sources
Molecules, 2013 In the past 30 years, only three natural products have been sources of new drugs with antiplatelet activity. In this study, we have demonstrated for the first time that guanosine from Solanum lycopersicum possesses antiplatelet (secretion, spreading ...
E. Fuentes +5 more
semanticscholar +3 more sources
The Potential Therapeutic Effect of Guanosine after Cortical Focal Ischemia in Rats
PLoS ONE, 2014 Background and Purpose Stroke is a devastating disease. Both excitotoxicity and oxidative stress play important roles in ischemic brain injury, along with harmful impacts on ischemic cerebral tissue.
G. Hansel +7 more
semanticscholar +3 more sources
Guanosine protects against glycerol-induced acute kidney injury via up-regulation of the klotho gene [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute Kidney Injury (AKI) is characterized by a rapid and reversible decline in renal function with a rapid decrease in Glomerular Filtration Rate (GFR), which is associated with high mortality. Rhabdomyolysis accounts for 10–40% of AKI, to
Rasha Ahmed +5 more
doaj +1 more source
The Isolation of Guanosine Tetraphosphate from Commercially Available Preparations of Guanosine Triphosphate [PDF]
Journal of Biological Chemistry, 1965 Jared Gardner, Mahlon B. Hoagland
openalex +3 more sources
Frontiers in Pharmacology, 2021 Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo +13 more
doaj +1 more source
Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
doaj +1 more source
Guanosine and its role in neuropathologies [PDF]
Purinergic Signalling, 2016 Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released in the brain under physiological conditions and even more during pathological events, reducing neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells.
L. Bettio, J. Gil-Mohapel, A. Rodrigues
semanticscholar +4 more sources