Results 11 to 20 of about 201,939 (380)

Extracellular Guanosine 5′-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine

Frontiers in Pharmacology, 2018
The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells.
Tiziana Pietrangelo, Ester S. Di Filippo, Marcello Locatelli, Francesco Piacenza, Marco Farina, Eleonora Pavoni, Andrea Di Donato, Denise Innosa, Mauro Provinciali, Stefania Fulle   +9 more
doaj   +2 more sources

Guanosine and its role in neuropathologies [PDF]

Purinergic Signalling, 2016
Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released in the brain under physiological conditions and even more during pathological events, reducing neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells.
Ana Lúcia S. Rodrigues, Joana Gil-Mohapel, Luis E.B. Bettio   +2 more
openaire   +4 more sources

Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40L

Molecules, 2013
In the past 30 years, only three natural products have been sources of new drugs with antiplatelet activity. In this study, we have demonstrated for the first time that guanosine from Solanum lycopersicum possesses antiplatelet (secretion, spreading ...
Iván Palomo, Claudio Valenzuela, Margarita Gutiérrez, Luis Astudillo, Marcelo Alarcón, Eduardo Fuentes   +5 more
doaj   +2 more sources

The potential therapeutic effect of guanosine after cortical focal ischemia in rats.

PLoS ONE, 2014
Background and purposeStroke is a devastating disease. Both excitotoxicity and oxidative stress play important roles in ischemic brain injury, along with harmful impacts on ischemic cerebral tissue. As guanosine plays an important neuroprotective role in
Gisele Hansel, Denise Barbosa Ramos, Camila Aguilar Delgado, Débora Guerini Souza, Roberto Farina Almeida, Luis Valmor Portela, André Quincozes-Santos, Diogo Onofre Souza   +7 more
doaj   +2 more sources

Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model

Frontiers in Psychiatry, 2021
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness.
Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Eduardo R. Zimmer, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza   +17 more
doaj   +1 more source

GUANOSINE DIPHOSPHATE MANNOSE [PDF]

Journal of Biological Chemistry, 1954
Blanco y ...
Cabib, Enrico, Leloir, Luis Federico
openaire   +2 more sources

Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
doaj   +1 more source

Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets. [PDF]

Journal of Clinical Investigation, 1998
We isolated and identified nucleoside(5') oligophospho-(5') nucleosides containing adenosine and guanosine (ApnG; n = 3-6) as well as diguanosine polyphosphates (GpnG; n = 3-6) in human platelets. For identification, UV spectrometry, matrix-assisted laser desorption/ionization, postsource decay matrix-assisted laser desorption/ionization mass ...
Martin Tepel, Raimund Kaufmann, I Grobeta, Jerzy-Roch Nofer, Hartmut Schlüter, Joachim Jankowski, Walter Zidek, Jürgen Bachmann, Michael Karas, M. van der Giet, Gerd Assmann   +10 more
openaire   +3 more sources

Guanosine Prevents Spatial Memory Impairment and Hippocampal Damage Following Amyloid-β_1–42 Administration in Mice

Metabolites, 2022
Alzheimer’s disease (AD) is a progressive neurodegenerative illness responsible for cognitive impairment and dementia. Accumulation of amyloid-beta (Aβ) peptides in neurons and synapses causes cell metabolism to unbalance, and the production of reactive ...
Victor Coelho, Luisa Bandeira Binder, Naiani Ferreira Marques, Leandra Celso Constantino, Gianni Mancini, Carla Inês Tasca   +5 more
doaj   +1 more source

SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]

, 2020
Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F, Jones-Carson, Jessica, Kant, Sashi, Kim, Ju-Sim, Liu, Lin, McClelland, Michael, Porwollik, Steffen, Till, James K, Vazquez-Torres, Andres   +8 more
core   +1 more source