Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]
, 2012 Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose +9 more
core +7 more sources
SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]
, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F +8 more
core +1 more source
Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]
, 2012 Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz +60 more
core +2 more sources
Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder
Frontiers in Pharmacology, 2017 Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson’s disease (PD), its ...
Caio M. Massari +10 more
doaj +1 more source
Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides
Molecules, 2020 Herein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives ...
Katherine Boback +5 more
doaj +1 more source
Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]
, 2017 Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma +6 more
core +2 more sources
Neuromodulatory Effects of Guanine-Based Purines in Health and Disease
Frontiers in Cellular Neuroscience, 2018 The function of guanine-based purines (GBPs) is mostly attributed to the intracellular modulation of heteromeric and monomeric G proteins. However, extracellular effects of guanine derivatives have also been recognized.
Carla I. Tasca +9 more
doaj +1 more source
Molecules, 2013 In the past 30 years, only three natural products have been sources of new drugs with antiplatelet activity. In this study, we have demonstrated for the first time that guanosine from Solanum lycopersicum possesses antiplatelet (secretion, spreading ...
Iván Palomo +5 more
doaj +1 more source
Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure [PDF]
, 2017 Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally ...
Albrecht +36 more
core +1 more source
Guanosine Protects Neuronal PC12 Cells from Serum Deprivation-induced Cell Death
Pteridines, 2012 Survival of neurons is dependent on the presence of trophic and non-trophic factors. Previous findings showed that purine nucleosides have the potential to rescue cells from hypoxia-induced cell death. Here we demonstrate that purine nucleoside guanosine
Thauerer Bettina +5 more
doaj +1 more source