Results 31 to 40 of about 164,412 (211)
Cell Reports Physical Science, 2020 Summary: Gel formation using guanosine self-assembly is an important process in supramolecular chemistry. Here, we report the stepwise construction of circularly polarized luminescent supramolecular organogels from self-assembled guanosine quadruplexes ...
Yanbin Zhang +4 more
doaj +1 more source
Antibiotics, 2021 Bacterial quorum sensing (QS) system regulates pathogenesis, virulence, and biofilm formation, and together they contribute to nosocomial infections. Opportunistic pathogens, such as Pseudomonas aeruginosa, rely on QS for regulating virulence factors ...
Itumeleng T. Baloyi +3 more
doaj +1 more source
Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice. [PDF]
PLoS ONE, 2015 Metabolic homeostasis is critical for all biological processes in the brain. The metabolites are considered the best indicators of cell states and their rapid fluxes are extremely sensitive to cellular changes.
Xi Chen +4 more
doaj +1 more source
Cladribine Analogues via O6-(Benzotriazolyl) Derivatives of Guanine Nucleosides
Molecules, 2015 Cladribine, 2-chloro-2′-deoxyadenosine, is a highly efficacious, clinically used nucleoside for the treatment of hairy cell leukemia. It is also being evaluated against other lymphoid malignancies and has been a molecule of interest for well over half a ...
Sakilam Satishkumar +11 more
doaj +1 more source
Scientific African, 2023 Multidrug-resistant (MDR) bacteria in biofilms are frequently linked with persistent infections across healthcare settings, due to their virulence factors.
Itumeleng T. Baloyi +3 more
doaj +1 more source
Rho GTPases in Skeletal Muscle Development and Homeostasis
Cells, 2021 Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj +1 more source
Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine. [PDF]
PLoS ONE, 2015 Modified nucleobase analogues can serve as powerful tools for changing physicochemical and biological properties of DNA or RNA. Guanosine derivatives containing bulky substituents at 8 position are known to adopt syn conformation of N-glycoside bond.
Daniel Sylwester Baranowski +3 more
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mBio, 2023 The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility ...
Aaron C. Nolan +7 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source