Results 31 to 40 of about 163,448 (315)

Modulation of phenylalanine and tyrosine concentrations by ischemia and guanosine in neuronal PC12 cells

Pteridines, 2013
Survival of neurons is dependent on the presence of trophic and non-trophic factors. We have previously observed the protective capacity of purine nucleosides in hypoxic neuronal cell cultures.
Thauerer Bettina, Geisler Simon, Fuchs Dietmar, Baier-Bitterlich Gabriele   +3 more
doaj   +1 more source

Construction of Supramolecular Organogel with Circularly Polarized Luminescence by Self-Assembled Guanosine Octamer

Cell Reports Physical Science, 2020
Summary: Gel formation using guanosine self-assembly is an important process in supramolecular chemistry. Here, we report the stepwise construction of circularly polarized luminescent supramolecular organogels from self-assembled guanosine quadruplexes ...
Yanbin Zhang, Ying He, Lukasz Wojtas, Xiaodong Shi, Hao Guo   +4 more
doaj   +1 more source

In Silico and In Vitro Screening of Antipathogenic Properties of Melianthus comosus (Vahl) against Pseudomonas aeruginosa

Antibiotics, 2021
Bacterial quorum sensing (QS) system regulates pathogenesis, virulence, and biofilm formation, and together they contribute to nosocomial infections. Opportunistic pathogens, such as Pseudomonas aeruginosa, rely on QS for regulating virulence factors ...
Itumeleng T. Baloyi, Idowu J. Adeosun, Abdullahi A. Yusuf, Sekelwa Cosa   +3 more
doaj   +1 more source

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice. [PDF]

PLoS ONE, 2015
Metabolic homeostasis is critical for all biological processes in the brain. The metabolites are considered the best indicators of cell states and their rapid fluxes are extremely sensitive to cellular changes.
Xi Chen, Chengsong Xie, Lixin Sun, Jinhui Ding, Huaibin Cai   +4 more
doaj   +1 more source

Cladribine Analogues via O6-(Benzotriazolyl) Derivatives of Guanine Nucleosides

Molecules, 2015
Cladribine, 2-chloro-2′-deoxyadenosine, is a highly efficacious, clinically used nucleoside for the treatment of hairy cell leukemia. It is also being evaluated against other lymphoid malignancies and has been a molecule of interest for well over half a ...
Sakilam Satishkumar, Prasanna K. Vuram, Siva Subrahmanyam Relangi, Venkateshwarlu Gurram, Hong Zhou, Robert J. Kreitman, Michelle M. Martínez Montemayor, Lijia Yang, Muralidharan Kaliyaperumal, Somesh Sharma, Narender Pottabathini, Mahesh K. Lakshman   +11 more
doaj   +1 more source

Biofilm reduction, in-vitro cytotoxicity and computational drug-likeness of selected phytochemicals to combat multidrug-resistant bacteria

Scientific African, 2023
Multidrug-resistant (MDR) bacteria in biofilms are frequently linked with persistent infections across healthcare settings, due to their virulence factors.
Itumeleng T. Baloyi, Idowu J. Adeosun, Francesca Bonvicini, Sekelwa Cosa   +3 more
doaj   +1 more source

Guanosine behind the scene [PDF]

Journal of Neurochemistry, 2013
Read the full article ‘Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions’ on doi: 10.1111/jnc ...
openaire   +2 more sources

Rho GTPases in Skeletal Muscle Development and Homeostasis

Cells, 2021
Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj   +1 more source

Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine. [PDF]

PLoS ONE, 2015
Modified nucleobase analogues can serve as powerful tools for changing physicochemical and biological properties of DNA or RNA. Guanosine derivatives containing bulky substituents at 8 position are known to adopt syn conformation of N-glycoside bond.
Daniel Sylwester Baranowski, Weronika Kotkowiak, Ryszard Kierzek, Anna Pasternak   +3 more
doaj   +1 more source

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

mBio, 2023
The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility ...
Aaron C. Nolan, Merve S. Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M. Corrigan, Angelika Gründling, James P. O’Gara   +7 more
doaj   +1 more source