Guanosine Attenuates Astrocyte-Associated Glutamatergic Dysregulation and Improves Survival in Acute Liver Failure-Induced Hepatic Encephalopathy [PDF]
MetabolitesBackground/Objectives: Acute liver failure (ALF) rapidly induces hepatic encephalopathy (HE), a severe neurological syndrome associated with astrocytic dysfunction and glutamatergic dysregulation.
Pedro Arend Guazzelli +8 more
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Pathway and Mechanism for the Biodegradation of Inosine and Guanosine by Heyndrickxia coagulans NJ01 [PDF]
FoodsHyperuricemia (HUA) and gout are primarily caused by excessive uric acid production resulting from the catabolism of purine nucleosides, notably inosine and guanosine.
Zhenyu Yuan +5 more
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The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus [PDF]
Antimicrobial Agents and ChemotherapyEfforts to improve the effectiveness of existing interventions for antimicrobial-resistant infections include identifying new ways to overcome resistance to licensed antibiotics using adjuvants or deploying antibiotics in novel combinations.
Aaron C. Nolan +6 more
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D81 Mutants Reveal Hidden EF-Tu Diversity while Natural Sequences Preserve Aspartate [PDF]
Computational and Structural Biotechnology JournalConformational dynamics are central to the function of many proteins, including the translational guanosine triphosphatase EF-Tu. AlphaFold2-based approaches such as AF-Cluster use sequence ensembles to sample alternative conformations, but most ...
Jordan L. Johnson, Yuhong Wang
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Isolation and Mechanistic Characterization of Pediococcus pentosaceus WQ-30 from Kimchi for Efficient In Vitro Purine Nucleoside Degradation Relevant to Hyperuricemia [PDF]
FoodsHyperuricemia (HUA) is a metabolic syndrome caused by elevated levels of uric acid (UA) serum, posing a significant threat to human health. Lactic acid bacteria degrade or adsorb UA precursors such as purine nucleosides and metabolites.
Qi Wu +5 more
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Guanosine protects against glycerol-induced acute kidney injury via up-regulation of the klotho gene [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute Kidney Injury (AKI) is characterized by a rapid and reversible decline in renal function with a rapid decrease in Glomerular Filtration Rate (GFR), which is associated with high mortality. Rhabdomyolysis accounts for 10–40% of AKI, to
Rasha Ahmed +5 more
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Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
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Frontiers in Pharmacology, 2021 Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo +13 more
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Role of Guanosine in Glycerol Induced Acute Renal Failure in Rats [PDF]
Minia Journal of Medical Research, 2020 Background: Acute renal failure (ARF) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address ARF are limited and warrant further studies.
Wael farouk +3 more
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Metabolites, 2022 Alzheimer’s disease (AD) is a progressive neurodegenerative illness responsible for cognitive impairment and dementia. Accumulation of amyloid-beta (Aβ) peptides in neurons and synapses causes cell metabolism to unbalance, and the production of reactive ...
Victor Coelho +5 more
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