Results 21 to 30 of about 164,412 (211)

Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
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Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model

Frontiers in Psychiatry, 2021
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness.
Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Eduardo R. Zimmer, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza   +17 more
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Synthesis of microporous hydrogen-bonded supramolecular organic frameworks through guanosine self-assembly

Cell Reports Physical Science, 2021
Summary: Extending the structural hierarchy and complexity through small-molecular self-assembly is a powerful way to obtain large discrete, functional molecular architecture.
Ying He, Yanbin Zhang, Mengjia Liu, Kai Zhao, Chuan Shan, Lukasz Wojtas, Hao Guo, Aishun Ding, Xiaodong Shi   +8 more
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Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides

Molecules, 2020
Herein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives ...
Katherine Boback, Katherine Bacchi, Sarah O’Neill, Samantha Brown, Jovelt Dorsainvil, Jillian E. Smith-Carpenter   +5 more
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Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder

Frontiers in Pharmacology, 2017
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson’s disease (PD), its ...
Caio M. Massari, Marc López-Cano, Marc López-Cano, Fabiana Núñez, Fabiana Núñez, Víctor Fernández-Dueñas, Víctor Fernández-Dueñas, Carla I. Tasca, Carla I. Tasca, Francisco Ciruela, Francisco Ciruela   +10 more
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Smartphone-Based Chemiluminescence Glucose Biosensor Employing a Peroxidase-Mimicking, Guanosine-Based Self-Assembled Hydrogel

Biosensors, 2023
Chemiluminescence is widely used for hydrogen peroxide detection, mainly exploiting the highly sensitive peroxidase-luminol-H2O2 system. Hydrogen peroxide plays an important role in several physiological and pathological processes and is produced by ...
Donato Calabria, Andrea Pace, Elisa Lazzarini, Ilaria Trozzi, Martina Zangheri, Massimo Guardigli, Silvia Pieraccini, Stefano Masiero, Mara Mirasoli   +8 more
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Neuromodulatory Effects of Guanine-Based Purines in Health and Disease

Frontiers in Cellular Neuroscience, 2018
The function of guanine-based purines (GBPs) is mostly attributed to the intracellular modulation of heteromeric and monomeric G proteins. However, extracellular effects of guanine derivatives have also been recognized.
Carla I. Tasca, Carla I. Tasca, Débora Lanznaster, Débora Lanznaster, Karen A. Oliveira, Karen A. Oliveira, Victor Fernández-Dueñas, Victor Fernández-Dueñas, Francisco Ciruela, Francisco Ciruela   +9 more
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Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40L

Molecules, 2013
In the past 30 years, only three natural products have been sources of new drugs with antiplatelet activity. In this study, we have demonstrated for the first time that guanosine from Solanum lycopersicum possesses antiplatelet (secretion, spreading ...
Iván Palomo, Claudio Valenzuela, Margarita Gutiérrez, Luis Astudillo, Marcelo Alarcón, Eduardo Fuentes   +5 more
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Guanosine Protects Neuronal PC12 Cells from Serum Deprivation-induced Cell Death

Pteridines, 2012
Survival of neurons is dependent on the presence of trophic and non-trophic factors. Previous findings showed that purine nucleosides have the potential to rescue cells from hypoxia-induced cell death. Here we demonstrate that purine nucleoside guanosine
Thauerer Bettina, Baeumer Bastian E., Fellner Lisa, Kuzdas Daniela, Ramberger Melanie, Baier-Bitterlich Gabriele   +5 more
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Modulation of phenylalanine and tyrosine concentrations by ischemia and guanosine in neuronal PC12 cells

Pteridines, 2013
Survival of neurons is dependent on the presence of trophic and non-trophic factors. We have previously observed the protective capacity of purine nucleosides in hypoxic neuronal cell cultures.
Thauerer Bettina, Geisler Simon, Fuchs Dietmar, Baier-Bitterlich Gabriele   +3 more
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