Results 221 to 230 of about 238,540 (308)

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Lack of nitric oxide‐ and guanosine 3′:5′‐cyclic monophosphate‐dependent regulation of α‐thrombin‐induced calcium transient in endothelial cells of spontaneously hypertensive rat hearts [PDF]

, 2000
Paola Failli, Alessandro Fazzini, Carlo Ruocco, Luca Mazzetti, Enrica Cecchi, Lisa Giovannelli, Fabio Marra, Stefano Milani, A Giotti   +8 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Gold Mono- and Bis-N-heterocyclic Carbenes Based on mRNA cap0. [PDF]

ACS Omega
Francescato G, Orsini G, Petronilho A.
europepmc   +1 more source

Isolation of Guanosine Diphosphate Uronic Acids from a Marine Brown Alga, Fucus gardneri Silva

, 1966
Tsau-Yen Lin, W. Z. Hassid
openalex   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Naphthyridine carbamate dimer ligand induces formation of Z-RNA-like fold of disease-related RNA and exhibits a molecular glue characteristics in crystal lattice formation. [PDF]

Nucleic Acids Res
Mateja-Pluta M, Błaszczyk L, Bejger M, Nakatani K, Kiliszek A.   +4 more
europepmc   +1 more source

Inhibition by adenine of Staphylococcus aureus growth in a nutrient medium free from guanine, guanosine, or hypoxanthine [PDF]

, 1966
J. de Repentigny, S Grimard, Patricia Turgeon, S Sonea   +3 more
openalex   +1 more source

Flexoelectric Polarization‐Enhanced Gd‐Based Nanoflowers for Efficient Phosphatase‐Mimicking Dephosphorylation

Small Structures, EarlyView.
Flexoelectric polarization is harnessed to dynamically enhance phosphatase‐mimicking catalysis in Gd‐based nanoflowers, enabling ultrasound‐responsive and efficient biophosphate ester hydrolysis through strain‐induced electronic modulation. Phosphatase‐mimicking nanozymes provide highly stable enzyme‐like activity but remain limited by their static ...
Linjing Su, Jingyan Xu, Rong Huang, Jinlan Liao, Lixue Zhao, Ling Li, Zhi Zhang, Yuhao Xiong   +7 more
wiley   +1 more source

Prodrug strategies in developing antiviral nucleoside analogs. [PDF]

RSC Med Chem
Suresh RR, Abuduani T, Kasthuri M, Chen Z, Tber Z, Loubidi M, Zhang H, Zhou L, Zhou S, Li C, Kumari A, Tao S, Wiseman JM, Hurwitz SJ, Amblard F, Schinazi RF.   +15 more
europepmc   +1 more source