Results 21 to 30 of about 238,540 (308)

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,, Bulgakov, Roman,, Haastert, Peter J.M. van,, Jastorff, Bernd,, Kesbeke, Fanja,, Morr, Michael,, Petridis, Georg,, Seela, Frank,, Stec, Wojciech J.,   +8 more
core   +2 more sources

Dynamics of Microtubule Growth and Catastrophe [PDF]

, 2007
We investigate a simple model of microtubule dynamics in which a microtubule evolves by: (i) attachment of guanosine triphosphate (GTP) to its end at rate lambda, (ii) GTP converting irreversibly to guanosine diphosphate (GDP) at rate 1, and (iii ...
Antal, T., Chakraborty, B., Krapivsky, P. L., Mailman, M., Redner, S.   +4 more
core   +1 more source

Modulation of phenylalanine and tyrosine concentrations by ischemia and guanosine in neuronal PC12 cells

Pteridines, 2013
Survival of neurons is dependent on the presence of trophic and non-trophic factors. We have previously observed the protective capacity of purine nucleosides in hypoxic neuronal cell cultures.
Thauerer Bettina, Geisler Simon, Fuchs Dietmar, Baier-Bitterlich Gabriele   +3 more
doaj   +1 more source

In Silico and In Vitro Screening of Antipathogenic Properties of Melianthus comosus (Vahl) against Pseudomonas aeruginosa

Antibiotics, 2021
Bacterial quorum sensing (QS) system regulates pathogenesis, virulence, and biofilm formation, and together they contribute to nosocomial infections. Opportunistic pathogens, such as Pseudomonas aeruginosa, rely on QS for regulating virulence factors ...
Itumeleng T. Baloyi, Idowu J. Adeosun, Abdullahi A. Yusuf, Sekelwa Cosa   +3 more
doaj   +1 more source

Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]

, 1975
Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Inaba, Kozo, Oda, Takuzo
core   +1 more source

Construction of Supramolecular Organogel with Circularly Polarized Luminescence by Self-Assembled Guanosine Octamer

Cell Reports Physical Science, 2020
Summary: Gel formation using guanosine self-assembly is an important process in supramolecular chemistry. Here, we report the stepwise construction of circularly polarized luminescent supramolecular organogels from self-assembled guanosine quadruplexes ...
Yanbin Zhang, Ying He, Lukasz Wojtas, Xiaodong Shi, Hao Guo   +4 more
doaj   +1 more source

Gastroprotective effects of oral nucleotide administration [PDF]

, 2006
BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A, Fitzgerald, A, Ghosh, S, Marchbank, T, Playford, RJ   +4 more
core   +2 more sources

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice. [PDF]

PLoS ONE, 2015
Metabolic homeostasis is critical for all biological processes in the brain. The metabolites are considered the best indicators of cell states and their rapid fluxes are extremely sensitive to cellular changes.
Xi Chen, Chengsong Xie, Lixin Sun, Jinhui Ding, Huaibin Cai   +4 more
doaj   +1 more source

Cladribine Analogues via O6-(Benzotriazolyl) Derivatives of Guanine Nucleosides

Molecules, 2015
Cladribine, 2-chloro-2′-deoxyadenosine, is a highly efficacious, clinically used nucleoside for the treatment of hairy cell leukemia. It is also being evaluated against other lymphoid malignancies and has been a molecule of interest for well over half a ...
Sakilam Satishkumar, Prasanna K. Vuram, Siva Subrahmanyam Relangi, Venkateshwarlu Gurram, Hong Zhou, Robert J. Kreitman, Michelle M. Martínez Montemayor, Lijia Yang, Muralidharan Kaliyaperumal, Somesh Sharma, Narender Pottabathini, Mahesh K. Lakshman   +11 more
doaj   +1 more source

Biofilm reduction, in-vitro cytotoxicity and computational drug-likeness of selected phytochemicals to combat multidrug-resistant bacteria

Scientific African, 2023
Multidrug-resistant (MDR) bacteria in biofilms are frequently linked with persistent infections across healthcare settings, due to their virulence factors.
Itumeleng T. Baloyi, Idowu J. Adeosun, Francesca Bonvicini, Sekelwa Cosa   +3 more
doaj   +1 more source