Results 51 to 60 of about 194,604 (252)
On the structural stability of guanosine-based supramolecular hydrogels.
Soft Matter, 2018 Supramolecular hydrogels formed from the self-assembly of low molecular weight derivatives are very attractive systems, because of their potential applications in nano- and bio-technology.
Federica Carducci +3 more
semanticscholar +1 more source
The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]
, 2018 Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
core +2 more sources
Frontiers in Bioengineering and Biotechnology, 2023 Tissue defects can lead to serious health problems and often require grafts or transplants to repair damaged soft tissues. However, these procedures can be complex and may not always be feasible due to a lack of available tissue.
Maria Merino-Gómez +6 more
doaj +1 more source
Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8 [PDF]
Physical Chemistry Chemical Physics 20, 3403-3410 (2018), 2018 Kinesin superfamily protein UNC-104, a member of the kinesin-3 family, transports synaptic vesicle precursors (SVPs). In this study, the number of active UNC-104 molecules hauling a single SVP in axons in the worm Caenorhabditis elegans was counted by applying a newly developed non-invasive force measurement technique.
arxiv +1 more source
Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Medicinal Chemistry Letters, 2017 Ras proteins are members of a large family of GTPase enzymes that are commonly mutated in cancer where they act as dominant oncogenes. We previously developed an irreversible guanosine-derived inhibitor, SML-8-73-1, of mutant G12C RAS that forms a ...
Yuan Xiong +11 more
semanticscholar +1 more source
Dietary nitrate enhances the contractile properties of human skeletal muscle [PDF]
, 2018 Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic ...
Coggan, Andrew R, Peterson, Linda R
core +2 more sources
Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
doaj +1 more source
In Search of Enzymes with a Role in 3′, 5′-Cyclic Guanosine Monophosphate Metabolism in Plants
Frontiers in Plant Science, 2016 In plants, nitric oxide (NO)-mediated 3′, 5′-cyclic guanosine monophosphate (cGMP) synthesis plays an important role during pathogenic stress response, stomata closure upon osmotic stress, the development of adventitious roots and transcript regulation ...
I. Gross, J. Durner
semanticscholar +1 more source
Suppressed renoprotective purines in COVID-19 patients with acute kidney injury
Scientific Reports, 2022 Acute kidney injury (AKI) is common in patients hospitalized for COVID-19, complicating their clinical course and contributing to worse outcomes. Animal studies show that adenosine, inosine and guanosine protect the kidney against some types of AKI ...
Edwin K. Jackson +7 more
doaj +1 more source
Microtubule catastrophe from protofilament dynamics [PDF]
Phys. Rev. E 88, 032717 (2013), 2013 The disappearance of the guanosine triphosphate (GTP)-tubulin cap is widely believed to be the forerunner event for the growth-shrinkage transition (`catastrophe') in microtubule filaments in eukaryotic cells. We study a discrete version of a stochastic model of the GTP cap dynamics, originally proposed by Flyvbjerg, Holy and Leibler (Flyvbjerg, Holy ...
arxiv +1 more source