Results 81 to 90 of about 266,483 (401)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

15N NMR study of a mixture of uniformly labeled tRNAs [PDF]

, 1982
15N NMR spectra were taken of 15N-enriched tRNA extracted from bakers yeast; ammonium sulfate was used as a nitrogen source. The increase in the degree of denaturation of tRNA, which occurs with increase in temperature from 30 degrees C to 70 degrees C ...
Birdseye, Theresa R., Gonnella, Nina C., Nee, Michael, Roberts, John D.   +3 more
core   +1 more source

Effects of Guanosine Tetraphosphate, Guanosine Pentaphosphate, and β-γ Methylenyl-Guanosine Pentaphosphate on Gene Expression of Escherichia coli In Vitro [PDF]

Proceedings of the National Academy of Sciences, 1974
The effects of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), both produced by E. coli , were measured on the activities of several genes in a cell-free system. Gene activity is measured as gene-directed synthesis of biochemically competent protein or transfer RNA.
Geoffrey Zubay, Elo Urm, Michael Cashel, Gary Reiness, Huey-Lang Yang   +4 more
openaire   +2 more sources

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate [PDF]

, 1992
1. In bovine adrenal chromaffin cells made permeable either to molecules less than or equal to 3 kDa with alphatoxin or to proteins less than or equal to 150 kDa with streptolysin O, the GTP analogues guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG)
Ahnert-Hilger, G., Gratzl, Manfred, Rosenthal, W., Spicher, K., Stecher, B., Wegenhorst, U.   +5 more
core  

RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]

, 2014
Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Aregger, Buratowski, Cansizoglu, Chook, Chu, Cowling, Cowling, Dormann, Fridell, Glover-Cutter, Gonatopoulos-Pournatzis, Lee, Li, Perales, Rebane, Shafer, Shatkin, Shuman, Suzuki, Süel, Thomas Gonatopoulos-Pournatzis, Topisirovic, Van Dusen, Victoria H. Cowling, Xu   +24 more
core   +4 more sources

Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii

Microbial Cell Factories, 2015
BackgroundInosine and guanosine monophosphate nucleotides are convenient sources of the umami flavor, with attributed beneficial health effects that have renewed commercial interest in nucleotide fermentations ...
Rodrigo Ledesma‐Amaro, R. Buey, J. Revuelta   +2 more
semanticscholar   +1 more source

A Scalable, Durable, Fire‐Safe All‐Day Passive Radiative Cooling Coating for Sustainable Buildings

Advanced Functional Materials, EarlyView.
This study reports a scalable, durable coating that combines a fire‑retardant copolymer adhesive, hollow glass microspheres, and boron oxide to achieve passive radiative cooling with over 94% solar reflectance and >95% mid‑infrared emissivity. The coating maintains performance after UV and rain exposure and exhibits UL‑94 V‑0 fire resistance, enabling ...
Zhewen Ma, Yuanhao Feng, Alex Y. Song, Toan Dinh, Min Hong, John Bell, Boyou Hou, Pingan Song, Wei Zheng   +8 more
wiley   +1 more source

Hierarchical Formation of Fibrillar and Lamellar Self-Assemblies from Guanosine-Based Motifs

Journal of Nucleic Acids, 2010
Here we investigate the supramolecular polymerizations of two lipophilic guanosine derivatives in chloroform by light scattering technique and TEM experiments.
Paolo Neviani, Dominique Sarazin, Marc Schmutz, Christian Blanck, Nicolas Giuseppone, Gian Piero Spada   +5 more
doaj   +1 more source

Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer [PDF]

, 2019
Genomic studies performed through liquid biopsies widely elucidated the evolutionary trajectory of RAS mutant clones under the selective pressure of EGFR inhibitors in patients with wild type RAS primary colorectal tumors. Similarly, the disappearance of
Belardinilli, Francesca, Cortesi, Enrico, Gazzaniga, Paola, Gelibter, ALAIN JONATHAN, Giannini, Giuseppe, Gradilone, Angela, Loreni, Flavia, Mahdavia, Yasaman, Nicolazzo, Chiara, Raimondi, Cristina   +9 more
core   +1 more source