Results 101 to 110 of about 37,457,458 (124)

Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates. [PDF]

Nat Chem
Zhang HJ, Ociepa M, Nassir M, Zheng B, Lewicki SA, Salmaso V, Baburi H, Nagel J, Mirza S, Bueschbell B, Al-Hroub H, Perzanowska O, Lin Z, Schmidt MA, Eastgate MD, Jacobson KA, Müller CE, Kowalska J, Jemielity J, Baran PS.   +19 more
europepmc   +1 more source

Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery. [PDF]

Nat Commun
Chen Z, Quirit Dudley J, Deniston C, Buffalo CZ, Patra D, Cao D, Hunt J, Rohaim A, Sengupta D, Wen L, Tsang T, Xie L, DiDonato M, Spraggon G, Clifton MC, Jarrousse N, Straimer J, Liang B.   +17 more
europepmc   +1 more source

Integrative Structure of Norovirus NS3 Suggests a Role in RNA Transport

Haas M, Mills JT, Kelley C, Das A, Hóf H, Niemel C, Donselaar T, Drulyte I, van Kuppeveld FJ, Dulin D, Snijder J, Herod MR, Hurdiss DL.   +12 more
europepmc   +1 more source

Guanosine 5′-O-(3-thiotriphosphate) causes endothelium-dependent, pertussis toxin-sensitive relaxations in porcine coronary arteries

Biochemical and Biophysical Research Communications, 1992
To determine whether direct stimulation of endothelial G-proteins causes relaxations of the underlying vascular smooth muscle, the effects of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and sodium fluoride were studied in porcine coronary arteries and endothelial cells.
Shibano, T, Codina, J, Vanhoutte, PM, Birnbaumer, L   +3 more
openaire   +5 more sources

2-[125I]iodomelatonin-binding sites in the human kidney and the effect of guanosine 5'-O-(3-thiotriphosphate)

Journal of Clinical Endocrinology & Metabolism, 1995
Putative melatonin receptors in normal kidney cortical tissues of patients with transitional cell carcinoma or renal cell carcinoma were characterized using a melatonin agonist, 2-[125I]iodomelatonin, as the radioligand. 2-[125I]Iodomelatonin-binding sites in the human kidney were stable, saturable, reversible, and of high affinity.
Y, Song, P C, Tam, A M, Poon, G M, Brown, S F, Pang   +4 more
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Differential effects of guanosine 5′-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleen

Neuroscience Letters, 1994
Effects of 10 and 50 mumol/l guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) on 2-[125I]iodomelatonin binding in the chicken bursa of Fabricius and spleen were tested. In the chicken bursa of Fabricius, GTP gamma S increased the Kd of 2-[125I]iodomelatonin binding sites without affecting the Bmax value.
Poon, AMS, Pang, SF
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Magnesium requirements for guanosine 5'-O-(3-thiotriphosphate) induced assembly of microtubule protein and tubulin

Biochemistry, 1986
Two conflicting interpretations on the role of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) in microtubule protein and tubulin assembly have been previously reported. One study finds that GTP gamma S promotes assembly while another study reports that GTP gamma S is a potent inhibitor of microtubule assembly.
S, Roychowdhury, F, Gaskin
openaire   +2 more sources

Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates

Biochemistry, 1987
Addition of the guanine nucleotide analogue guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) to [3H]inositol-labeled NRK cell homogenates resulted in rapid breakdown of cellular polyphosphoinositides. GTP gamma S stimulated phospholipase C, resulting in a more than 4-fold increase in the hydrolysis rates of phosphatidylinositol 4-phosphate (PIP) and ...
S B, Chahwala, L F, Fleischman, L, Cantley   +2 more
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Induction of granule release by intracellular application of calcium and guanosine-5′-O-(3-thiotriphosphate) in human eosinophils

Journal of Allergy and Clinical Immunology, 1992
The roles of Ca and G proteins in granule release from human eosinophils were examined by use of a patch-clamp technique in single cells. The morphologic changes and the release of eosinophil peroxidase (EPO) from single cells were simultaneously observed. In addition, the expression of small molecular weight guanine nucleotide binding protein (small G
T, Aizawa, Y, Kakuta, K, Yamauchi, Y, Ohkawara, N, Maruyama, Y, Nitta, G, Tamura, H, Sasaki, T, Takishima   +8 more
openaire   +2 more sources