Results 31 to 40 of about 2,866 (140)

The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells [PDF]

, 1992
Thyrotropin-releasing hormone stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in GH3 cell membranes. The stimulation of the phosphoinositide phospholipase C (PI/PLC) activity can be blocked by incubation of GH3 membranes with ...
Aragay, Anna M., Katz, Arieh, Simon, Melvin I.   +2 more
core  

Reduction of Muscarinic Receptor Density and of Guanine Nucleotide-Stimulated Phosphoinositide Hydrolysis in Human SH-SY5Y Neuroblastoma Cells Following Long-Term Treatment with 12- O -Tetradecanoylphorbol 13-Acetate or Mezerein [PDF]

, 1990
The actions of tumor promoters on the coupling of muscarinic receptors to the hydrolysis of inositol lipids and the generation of Ca 2+ signals were examined in the human neuroblastoma SH-SY5Y cell line.
Cioffi, Catherine L., Fisher, Stephen K.
core   +1 more source

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells [PDF]

, 2011
Background α2-adrenergic receptors (ARs) mediate many cellular actions of epinephrine and norepinephrine and inhibit their secretion from adrenal chromaffin cells.
Kassimatis, Theodoros, Lymperopoulos, Anastasios, Nguyen, Kristy   +2 more
core   +3 more sources

Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity.

Journal of Biological Chemistry, 1981
The guanine nucleotide regulatory protein component (N) of the frog erythrocyte membrane adenylate cyclase system appears to form a stable complex with the beta-adrenergic receptor (R) in the presence of agonist (H). This agonist-promoted ternary complex HRN can be solubilized with Lubrol.
J M, Stadel, R G, Shorr, L E, Limbird, R J, Lefkowitz   +3 more
openaire   +2 more sources

Coupling Efficacy and Selectivity of the Human Μ-Opioid Receptor Expressed as Receptor—GΑ Fusion Proteins in Escherichia coli [PDF]

, 2000
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65628/1/j.1471-4159.2000.0751190.x ...
Alt, Befort, Bertin, Blake, Bradford, Burt, Chakrabarti, Chakrabarti, Chan, Fan, Ferguson, Gaibelet, Jockers, Jones, Kieffer, Laugwitz, Law, Leff, Mestek, Milligan, Murthy, Prather, Prather, Sanchez-Blazquez, Satoh, Seifert, Seifert, Seifert, Sim, Stanasila, Sternini, Taylor, Ueda, Van den Broeck, Waldhoer, Whistler, Wise, Yang, Zadina, Zhang   +39 more
core   +1 more source

On the Gating Mechanisms of the Light-dependent Conductance in Pecten Hyperpolarizing Photoreceptors: Does Light Remove Inactivation in Voltage-dependent K Channels? [PDF]

, 2005
The hyperpolarizing receptor potential of ciliary photoreceptors of scallop and other mollusks is mediated by a cGMP-activated K conductance; these cells also express a transient potassium current triggered by depolarization.
del Pilar Gomez, Maria, Nasi, Enrico
core   +2 more sources

Molecular Requirements for Ethanol Differential Allosteric Modulation of Ligand-Gated Ion Channels Based on Selective G Beta Gamma Modulation [PDF]

, 2010
It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure.
Aguayo, Luis G, Avila, Ariel, Figueroa, Maximiliano, Guzman, Leonardo, Moraga-Cid, Gustavo, Peoples, Robert W., Yevenes, Gonzalo E   +6 more
core   +1 more source

Prostaglandin receptors and role of G protein-activated pathways on corpora lutea of pseudopregnant rabbit in vitro [PDF]

, 2001
Studies were conducted to characterize receptors for prostaglandin (PG) F(2alpha) (PGF(2alpha)) and PGE(2), and the signalling pathways regulating total nitric oxide synthase activity and progesterone production in rabbit corpora lutea (CL) of different ...
BOITI C, GOBBETTI, Anna, GUELFI G., ZAMPINI D, ZERANI, Massimo   +4 more
core   +1 more source

Carbachol in the presence of guanosine 5′-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes

Journal of Biological Chemistry, 1989
The breakdown of exogenously added [3H]inositol-labeled phosphoinositides by rat brain cortical membranes was stimulated by the muscarinic cholinergic agonist carbachol. The stimulation required the presence of guanine nucleotide. Optimal conditions were similar to those described for guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) + carbachol ...
E, Claro, M A, Wallace, H M, Lee, J N, Fain   +3 more
openaire   +2 more sources

Guanosine 5'-O-(3-thiotriphosphate) as an analog of GTP in protein biosynthesis. The effects of temperature and polycations on the accuracy of initial recognition of aminoacyl-tRNA ternary complexes by ribosomes.

Journal of Biological Chemistry, 1986
Guanosine 5'-O-(3-thio)triphosphate (GTP gamma S) is a good analog of GTP in the reactions leading to the formation of a peptide bond in protein biosynthesis. It forms binary and ternary complexes with elongation factor Tu (EF-Tu), and with EF-Tu and aminoacyl-tRNA (aa-tRNA). In addition, it stimulates aa-tRNA binding to ribosomes. Although GTP gamma S
A M, Karim, R C, Thompson
openaire   +2 more sources