Results 51 to 60 of about 6,222 (140)

Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells

, 2020
The effects of 100 μM of 3',5'-cGMP, cAMP, cCMP, and cUMP as well as of the corresponding membrane-permeant acetoxymethyl esters on anti-CD3-antibody (OKT3)-induced IL-2 production of HuT-78 cutaneous T cell lymphoma (Sézary lymphoma) cells were analyzed.
Schneider, Erich H., Seifert, Roland, Hofmeister, Olga, Kälble, Solveig   +3 more
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Mecanismos de neuroproteção da guanosina contra a neurotoxicidade induzida por isquemia e dano oxidativo mitocondrial in vitro [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasA guanosina (GUO) é um modulador endógeno da excitotoxicidade glutamatérgica e promove neuroproteção em modelos de ...
Dal-Cim, Tharine Aparecida
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Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons

, 1989
Externally applied gamma-aminobutyric acid (GABA) quickly and reversibly reduces by 60% voltage activated Ca2+ currents in chick dorsal root ganglion cells.
GRASSI, Francesca, H. D. Lux
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Effects of Guanosine 5'-O-(3-Thiotriphosphate) on 2-[¹²⁵I]Iodomelatonin Binding in the Chicken Lung, Brain and Kidney: Hypothesis of Different Subtypes of High Affinity Melatonin Receptors

Neurosignals, 1993
Effects of 10 mumol/l guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S), a non-hydrolyzable analog of guanosine 5'-triphosphate, on 2-[125I]iodomelatonin binding were investigated. In the chicken lung, 10 mumol/l GTP gamma S significantly increased (p < 0.05) the equilibrium dissociation constant (Kd) values, but did not affect the maximum number of ...
Song, Y, Pang, SF, Ayre, EA, Poon, AMS, Pang, CS, Yuan, H, Wang, ZP, Brown, GM   +7 more
openaire   +3 more sources

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

Journal of Biological Chemistry, 1991
Receptor-linked activation of phospholipase D has been demonstrated recently in a variety of intact cell types including granulocytes, but little is known about the enzyme, its cofactor requirements, and regulation. Using [3H]alkyllysophosphatidylcholine to prelable an endogenous phosphatidylcholine substrate pool in conjunction with ...
S C, Olson, E P, Bowman, J D, Lambeth
openaire   +2 more sources

Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni.

Journal of Biological Chemistry, 1987
The effect of the addition of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S), the GTP analog which activates the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni), on the pertussis toxin-mediated ADP-ribosylation reaction was studied in detail.
R, Mattera, J, Codina, R D, Sekura, L, Birnbaumer   +3 more
openaire   +2 more sources

Caffeine inhibits cytoplasmic Ca2+ oscillations induced by carbachol and guanosine 5'-O-(3-thiotriphosphate) in hyperpolarized pancreatic beta-cells

, 1994
The effects of caffeine on cytoplasmic Ca2+ oscillations induced by carbachol and guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) were studied in individual mouse pancreatic beta-cells clamped at a hyperpolarized potential.
Gylfe, E, Lund, P E
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CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]

, 2012
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick, Albert C Ludolph, Hans A Kretzschmar, Ludolph, Albert C., Markus Otto, Kretzschmar, Hans A., Petra Steinacker, Stefan Lehnert, Ferger Boris, Patrick Oeckl, Otto, Markus, Ferger, Boris, Oeckl Patrick, Ludolph Albert C., Boris Ferger, Steinacker, Petra, Otto Markus, Lehnert Stefan, Steinacker Petra, Kretzschmar Hans A., Jesse, Sarah, Lehnert, Stefan, Sarah Jesse, Jesse Sarah   +23 more
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O efeito trófico dos derivados da guanina em culturas de astrócitos e neurônios cerebelares [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foi avaliado o efeito de GMP ou Guanosina em três diferentes situações: o efeito trófico sobre ...
Decker, Helena
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Design and Synthesis of novel amphiphilic Guanosine-based Nucleolipids

, 2010
We here describe the preparation of a small library of amphiphilic guanosine derivatives, functionalized with fatty acids or lipid derivatives at the 2’ and 3’-OH moieties and incorporating different hydrophilic group at the 5’-OH position, starting from
DE NAPOLI, LORENZO, MONTESARCHIO, DANIELA, SIMEONE, LUCA, Domenico Milano   +3 more
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