Results 31 to 40 of about 6,222 (140)

Identification of Physiologically Active Substances as Novel Ligands for MRGPRD

BioMed Research International, Volume 2012, Issue 1, 2012., 2012
Mas‐related G‐protein coupled receptor member D (MRGPRD) is a G protein‐coupled receptor (GPCR) which belongs to the Mas‐related GPCRs expressed in the dorsal root ganglia (DRG). In this study, we investigated two novel ligands in addition to beta‐alanine: (1) beta‐aminoisobutyric acid, a physiologically active substance, with which possible relation ...
Makiko Uno, Satoko Nishimura, Keisuke Fukuchi, Yasuyuki Kaneta, Yoko Oda, Hironobu Komori, Shigeki Takeda, Tatsuya Haga, Toshinori Agatsuma, Futoshi Nara, S. L. Mowbray   +10 more
wiley   +1 more source

Mechanisms in bradykinin stimulated arachidonate release and synthesis of prostaglandin and platelet activating factor

Mediators of Inflammation, Volume 1, Issue 2, Page 133-140, 1992., 1992
Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). A role for GTP binding protein (G‐protein) in the binding of BK to the cells was determined.
D. Ricupero, L. Taylor, A. Tlucko, J. Navarro, P. Polgar   +4 more
wiley   +1 more source

Muscarinic acetylcholine receptor‐stimulated binding of guanosine 5′‐O‐(3‐thiotriphosphate) to guanine‐nucleotide‐binding proteins in cardiac membranes [PDF]

European Journal of Biochemistry, 1989
Receptor‐regulated binding of the labeled GTP analog, guanosine 5′‐O‐(3‐thiotriphosphate) ([35S]GTP[S]), to guanine‐nucleotide‐binding proteins (G‐proteins) was studied in porcine atrial membranes enriched in muscarinic acetylcholine (mACh) receptors. Binding of [35S]GTP[S] to the membranes was not or only slightly affected by the cholinergic agonist ...
G, Hilf, P, Gierschik, K H, Jakobs
openaire   +2 more sources

Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.

Journal of Biological Chemistry, 1990
L'ajout de guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) à des fibroblastes pulmonaires intacts de hamster chinois (CCL39) dépolarisés par des concentrations élevées de K+ entraîne l'activation de la phospholipase C spécifique du phosphoinositide (PLC) (à des concentrations de GTP gamma S supérieures à 0,1 mM), l'inhibition de l'adénylate cyclase ...
S Paris, Jacques Pouysségur
openaire   +2 more sources

STOMATAL OPENING IS INDUCED IN EPIDERMAL PEELS OF COMMELINA-COMMUNIS L BY GTP ANALOGS OR PERTUSSIS TOXIN [PDF]

, 1993
Pretreatment with pertussis toxin or microinjection of guanosine-5'-(3-thiotriphosphate) (GTP-gamma-S) into guard cells in peeled epidermis of Commelina communis L. promoted stomatal opening under subsaturating white light.
LEE, YS, CRAIN, RC, LEE, HJ, TUCKER, EB
core   +1 more source

Guanosine nucleotide-dependent activation of the amiloride-blockable Na+ channel

, 1989
Effects of guanosine nucleotides on the epithelial Na+ channel were studied in apical membrane vesicles derived from the toad bladder epithelium. Trapping 10 microM guanosine-5'-O-(thiotriphosphate) (GTP gamma S) in vesicles evoked two- to fourfold ...
H. Garty, A. Yanovsky, O. Yeger, C. Asher   +3 more
core   +1 more source

Guanosine 5´-O-(3-Thiotriphosphate) and Cations Regulate Melatonin Receptors, and Melatonin Inhibits Cyclic AMP Production in the Spinal Cord

Neurosignals, 1997
Effects of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and cations on 2-[125I]iodomelatonin binding were investigated in membrane preparations of the chicken spinal cord. At concentrations of 10 and 50 mumol/l, GTP gamma S dose-dependently increased (p < 0.05) the equilibrium dissociation constant (Kd) and depressed (p < 0.05) the maximum number ...
Q, Wan, M X, Liao, C S, Pang, S F, Pang, G M, Brown   +4 more
openaire   +2 more sources

Binding and unbinding of potent melatonin receptor ligands: Mechanistic simulations and experimental evidence

Journal of Pineal Research, Volume 76, Issue 2, March 2024.
Abstract The labeled ligand commonly employed in competition binding studies for melatonin receptor ligands, 2‐[125I]iodomelatonin, showed slow dissociation with different half‐lives at the two receptor subtypes. This may affect the operational measures of affinity constants, which at short incubation times could not be obtained in equilibrium ...
Annalida Bedini, Gian Marco Elisi, Fabiola Fanini, Michele Retini, Laura Scalvini, Silvia Pasquini, Chiara Contri, Katia Varani, Gilberto Spadoni, Marco Mor, Fabrizio Vincenzi, Silvia Rivara   +11 more
wiley   +1 more source

Chlorine Dioxide Oxidation of Guanosine 5‘-Monophosphate

, 2016
The reactions between aqueous ClO2 and guanosine 5‘-monophosphate (5‘-GMP) are investigated from pH 5.96 to 8.30. The decay of ClO2 follows mixed first-order and second-order kinetics.
Dale W. Margerum (2451712), David J. Stewart (169981), Michael J. Napolitano (2451715)   +2 more
core   +2 more sources

Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner. [PDF]

, 2014
Identifying and characterising potential new therapeutic agents to target cell proliferation may provide improved treatments for neoplastic disorders such as cancer and polycystic ...
Baines, D, Williams, R.S.B., Dinh, C, Ludtmann, M H R, Waheed, A., Ludtmann, M.H.R., Pakes, N, Carew, M., Williams, RS, Pakes, N., Robery, S, Carew, MA, Waheed, A, Ludtmann, MH, Kuspa, A, Robery, S., Kuspa, A., Baines, D., Carew, M A, Williams, R S, Dinh, C.   +20 more
core   +1 more source