Results 31 to 40 of about 37,457,458 (124)

Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides [PDF]

, 2010
We show that UVA irradiation (365 nm) of the Pt-IV complex trans,trans,trans-[(PtCl2)-Cl-IV(OH)(2)(dimethylamine) (isopropylamine)] (1), induces reduction to Pt-II photoproducts.
Pizarro, Ana M., Sadler, P. J., Cubo, Leticia, Navarro-Ranninger, Carmen, Salassa, Luca, Quiroga, Adoracion G.   +5 more
core   +1 more source

Effects of Guanosine 5'-O-(3-Thiotriphosphate) on 2-[¹²⁵I]Iodomelatonin Binding in the Chicken Lung, Brain and Kidney: Hypothesis of Different Subtypes of High Affinity Melatonin Receptors

Neurosignals, 1993
Effects of 10 mumol/l guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S), a non-hydrolyzable analog of guanosine 5'-triphosphate, on 2-[125I]iodomelatonin binding were investigated. In the chicken lung, 10 mumol/l GTP gamma S significantly increased (p < 0.05) the equilibrium dissociation constant (Kd) values, but did not affect the maximum number of ...
Song, Y, Pang, SF, Ayre, EA, Poon, AMS, Pang, CS, Yuan, H, Wang, ZP, Brown, GM   +7 more
openaire   +3 more sources

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

Journal of Biological Chemistry, 1991
Receptor-linked activation of phospholipase D has been demonstrated recently in a variety of intact cell types including granulocytes, but little is known about the enzyme, its cofactor requirements, and regulation. Using [3H]alkyllysophosphatidylcholine to prelable an endogenous phosphatidylcholine substrate pool in conjunction with ...
S C, Olson, E P, Bowman, J D, Lambeth
openaire   +2 more sources

Mecanismos de neuroproteção da guanosina contra a neurotoxicidade induzida por isquemia e dano oxidativo mitocondrial in vitro [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasA guanosina (GUO) é um modulador endógeno da excitotoxicidade glutamatérgica e promove neuroproteção em modelos de ...
Dal-Cim, Tharine Aparecida
core  

Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni.

Journal of Biological Chemistry, 1987
The effect of the addition of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S), the GTP analog which activates the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni), on the pertussis toxin-mediated ADP-ribosylation reaction was studied in detail.
R, Mattera, J, Codina, R D, Sekura, L, Birnbaumer   +3 more
openaire   +2 more sources

Caffeine inhibits cytoplasmic Ca2+ oscillations induced by carbachol and guanosine 5'-O-(3-thiotriphosphate) in hyperpolarized pancreatic beta-cells

, 1994
The effects of caffeine on cytoplasmic Ca2+ oscillations induced by carbachol and guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) were studied in individual mouse pancreatic beta-cells clamped at a hyperpolarized potential.
Gylfe, E, Lund, P E
core  

Glutamate-Stimulated, Guanine Nucleotide-Mediated Phosphoinositide Turnover in Astrocytes Is Inhibited by Cyclic AMP [PDF]

, 1990
The potential for cross-talk between the adenyl cy-clase and phosphoinositide (PPI) lipid second messenger system was investigated in astrocytes cultured from neonatal rat brain.
George R. Bruno, Patricia L. Robertson, Bruno, George R., Robertson, Patricia L., Subhash C. Datta, Datta, Subhash C.   +5 more
core   +1 more source

Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells

, 2020
The effects of 100 μM of 3',5'-cGMP, cAMP, cCMP, and cUMP as well as of the corresponding membrane-permeant acetoxymethyl esters on anti-CD3-antibody (OKT3)-induced IL-2 production of HuT-78 cutaneous T cell lymphoma (Sézary lymphoma) cells were analyzed.
Schneider, Erich H., Seifert, Roland, Hofmeister, Olga, Kälble, Solveig   +3 more
core   +1 more source

Preparation of 5'-O-(1-Thiotriphosphate)-modified oligonucleotides using polymerase-endonuclease amplification reaction (PEAR). [PDF]

, 2013
Antisense oligonucleotides (ASODNs) have been widely used as an important tool for regulating gene expression, and developed into therapeutics. Natural ODNs are susceptible to nuclease degradation, nucleic acid analogues, however, have less side effects,
Jianye Zhang, Xinhong Zhu, Shihua Dong (430970), Jiajun Wu (430971), Biao Li (36684), Quanjiang Dong (430973), Xiaolong Wang, Shihua Dong, Jianye Zhang (430972), Gang Chen (107840), Xinhong Zhu (430974), Biao Li, Jiajun Wu, Quanjiang Dong, Gang Chen, Xiaolong Wang (20235)   +15 more
core   +1 more source

Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons

, 1989
Externally applied gamma-aminobutyric acid (GABA) quickly and reversibly reduces by 60% voltage activated Ca2+ currents in chick dorsal root ganglion cells.
GRASSI, Francesca, H. D. Lux
core   +1 more source