Results 81 to 90 of about 118,645 (287)

Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs

Cells, 2019
Breast cancer is the most common malignant tumors in females. Although the conventional treatment has demonstrated a certain effect, some limitations still exist.
Yu Zhang, Jun Li, Xing-Ning Lai, Xue-Qiao Jiao, Jun-Ping Xiong, Li-Xia Xiong   +5 more
doaj   +1 more source

Phosphoproteins and protein-kinase activity in isolated envelopes of pea (Pisum sativum L.) chloroplasts [PDF]

, 1985
A protein kinase was found in envelope membranes of purified pea (Pisum sativum L.) chloroplasts. Separation of the two envelope membranes showed that most of the enzyme activity was localized in the outer envelope.
D.G. Robinson, G. Mourioux, G.M. Hathaway, H.Y. Nakatani, J. Joyard, J. Pfisterer, J. Soll, J. Soll, K. Cline, K. Cline, M.A. Block, O.H. Lowry, R. Douce, R. Douce, T.J. Yan, U.J. Flügge, W.A. Laing, Z.F. Lin   +17 more
core   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Transmembrane transport of the nucleotides cAMP (cyclic adenosine monophosphate) and AMP (adenosine monophosphate) is challenging, but can be achieved using a two‐component system consisting of a synthetic anionophore (e.g., squaramides) and a lipophilic thymine derivative.
Uththara M.C. Rathnaweera, Olivia Sam, Karolis Norvaisa, Sarah R. Marshall, Randima D. De Silva Weerakonda Arachchige, Matúš Chvojka, Hennie Valkenier, Nathalie Busschaert   +7 more
wiley   +2 more sources

Purification, crystallization and preliminary X-ray crystallographic analysis of human ppGpp hydrolase, Mesh1

Journal of Analytical Science and Technology, 2010
Bacterial SpoT is a Mn2+-dependent pyrophosphohydrolase to hydrolyze guanosine 3’-diphosphate-5’-diphosphate to guanosine diphosphate and pyrophosphate.
Dawei Sun, Hye-Yeon Kim, Young Ho Jeon
doaj  

Evolution of the bacterial nucleosidase PpnN and its relation to the stringent response

Microbial Cell, 2019
In our recent publication (Zhang et al., 2019), we demonstrate an interesting mode of regulation of purine metabolism unique to Proteobacteria. In this microreview, we would like to reflect on the ideas put forward, with special focus on protein domain ...
René Lysdal Bærentsen, Ditlev Egeskov Brodersen, Yong Everett Zhang   +2 more
doaj   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Post-Translational Modification and Subcellular Distribution of Rac1: An Update

Cells, 2018
Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla Abdrabou, Zhixiang Wang
doaj   +1 more source