Results 71 to 80 of about 30,288 (231)

Covalent Guanosine Mimetic Inhibitors of G12C KRAS

, 2016
Ras proteins are members of a large family of GTPase enzymes that are commonly mutated in cancer where they act as dominant oncogenes. We previously developed an irreversible guanosine-derived inhibitor, SML-8-73-1, of mutant G12C RAS that forms a ...
Taebo Sim (806344), John Hunter (1349355), Jia Lu (181094), Hwan Geun Choi (750017), Lianbo Li (3545675), Sudershan Gondi (3545678), Yuan Xiong (40206), Nathanael S. Gray (150685), Sang Min Lim (1484440), David Scott (152448), Kenneth D. Westover (1349343), Anuj Manandhar (3545672)   +11 more
core   +1 more source

Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years

Clinical Interventions in Aging, 2023
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B, Kusy K, Slominska EM, Ciekot-Sołtysiak M, Zieliński J   +4 more
doaj  

Anti-cancer Effects of a Chemically Modified miR-143 on Bladder Cancer by Either Systemic or Intravesical Treatment

Molecular Therapy: Methods & Clinical Development, 2019
We developed a novel chemically modified miR-143 (miR-143#12), and with it we investigated the contribution of miR-143 to the pathogenesis of bladder cancer (BC), in which miR-143 is extremely downregulated.
Yuki Yoshikawa, Kohei Taniguchi, Takuya Tsujino, Kazuki Heishima, Teruo Inamoto, Tomoaki Takai, Koichiro Minami, Haruhito Azuma, Kanjiro Miyata, Kotaro Hayashi, Kazunori Kataoka, Yukihiro Akao   +11 more
doaj   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Amplification and cloning of guanosine 5'-triphosphate, 3'- diphosphate phosphohydrolase enzyme from Mycobacterium tuberculosis

, 2020
Mycobacterium tuberculosis, the etiological agent of human tuberculosis (TB), is one of the most successful bacterial pathogens, remaining a leading cause of morbidity and mortality.
Bruno Lopes Abbadi, Luiz Augusto Basso, Diógenes Santiago Santos, Zilpa Adriana Sánchez Quitian   +3 more
core  

DNA Synthesis of the PhiX Genomic DNA library from Deoxynucleotide Diphosphate Substrates [PDF]

, 2022
DNA synthesis is an essential process necessary for the survival of living organisms. This biochemical event is important for self-maintenance and is even required to pass down genetic information to future offspring.
Argelagos, Allan
core  

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Stringent control of RNA synthesis in the absence of guanosine 5‘-diphosphate-3‘-diphosphate.

Journal of Biological Chemistry, 1981
Severe curtailment of RNA synthesis and widespread readjustment of cellular activities, together with an increase of guanosine 5'-diphosphate-3'-diphosphate (ppGpp) have been demonstrated in Escherichia coli cells starved for amino acid or energy. The rates of growth and RNA synthesis are reduced by shifting the growth temperature from 40 degrees C to ...
C C, Pao, B T, Dyess
openaire   +2 more sources

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Borrelia Burgdorferi Rel Is Responsible for Generation of Guanosine-3′-Diphosphate-5′-Triphosphate and Growth Control

, 2005
The global transcriptional regulator (p)ppGpp (guanosine-3\u27-diphosphate-5\u27-triphosphate and guanosine-3\u27,5\u27-bisphosphate, collectively) produced by the relA and spoT genes in Escherichia coli allows bacteria to adapt to different ...
Bryksin, Anton V., Bugrysheva, Julia, Godfrey, Henry P., Cabello, Felipe C.   +3 more
core   +1 more source