Results 71 to 80 of about 66,472 (220)

Transcriptomics combined with metabolomics unveiled the key genes and metabolites of mycelium growth in Morchella importuna

Frontiers in Microbiology, 2023
Morels (Morchella) are one of the most popular edible fungi in the world, especially known for their rich nutrition and delicious taste. Earlier research indicates that the production of fruiting bodies can be affected by the growth of mycelium.
Tingting Fan, Rui Ren, Shaojun Tang, Yiyun Zhou, Meng Cai, Wenwen Zhao, Yuelin He, Jun Xu   +7 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

The relationship between guanosine tetraphosphate, polysomes and RNA synthesis in amino acid starved Escherichia coli.

, 1978
International audienceA relA+ strain of E. coli with four amino acid requirements was starved separately for each amino acid, after which the levels of polysomes, guanosine-5'-diphosphate-3'-diphosphate and the residual net synthesis of RNA were ...
Santonastaso, V., Roche, J., Cozzone, Aj, Donini, P.   +3 more
core   +3 more sources

Conserved Golgi nucleoside diphosphatases drive protein glycosylation and virulence in Fusarium graminearum

Phytopathology Research
The Golgi apparatus orchestrates post-translational modification and vesicular trafficking, with guanosine diphosphatases (GDPases) facilitating nucleotide-sugar transport by hydrolyzing guanosine diphosphate (GDP) to guanosine monophosphate (GMP ...
Soobin Shin, Yejin Choi, Thuy Thi Thanh Phan, Seonwoo Song, Nahyun Lee, Jiyeun Park, Sieun Kim, Hosung Jeon, Jung-Eun Kim, Kyunghun Min, Hun Kim, Gyung Ja Choi, Hyun Ah Kang, Dae-Geun Song, Hokyoung Son   +14 more
doaj   +1 more source

Post-Translational Modification and Subcellular Distribution of Rac1: An Update

Cells, 2018
Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla Abdrabou, Zhixiang Wang
doaj   +1 more source

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

Integrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu, Xiang‐Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong   +5 more
wiley   +1 more source

Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years

Clinical Interventions in Aging, 2023
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B, Kusy K, Slominska EM, Ciekot-Sołtysiak M, Zieliński J   +4 more
doaj  

Anti-cancer Effects of a Chemically Modified miR-143 on Bladder Cancer by Either Systemic or Intravesical Treatment

Molecular Therapy: Methods & Clinical Development, 2019
We developed a novel chemically modified miR-143 (miR-143#12), and with it we investigated the contribution of miR-143 to the pathogenesis of bladder cancer (BC), in which miR-143 is extremely downregulated.
Yuki Yoshikawa, Kohei Taniguchi, Takuya Tsujino, Kazuki Heishima, Teruo Inamoto, Tomoaki Takai, Koichiro Minami, Haruhito Azuma, Kanjiro Miyata, Kotaro Hayashi, Kazunori Kataoka, Yukihiro Akao   +11 more
doaj   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source