Elevated levels of plasma phenylalanine in schizophrenia: a guanosine triphosphate cyclohydrolase-1 metabolic pathway abnormality? [PDF]
PLoS ONE, 2014 BACKGROUND: Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia.
Olaoluwa Okusaga +15 more
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A Small Guanosine Triphosphate Binding Protein PagRabE1b Promotes Xylem Development in Poplar [PDF]
Frontiers in Plant Science, 2021 Rab GTPases are the subfamily of the small guanosine triphosphate (GTP)-binding proteins which participated in the regulation of various biological processes. Recent studies have found that plant Rabs play some specific functions.
Ying-Li Liu +8 more
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Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells [PDF]
BiologyIntravenously transplanted mesenchymal stromal cells (MSCs) have been shown to interact with endothelial cells and to migrate to tissues. However, intracellular signals regulating MSC migration are still incompletely understood.
Melanie Giesen +4 more
doaj +2 more sources
In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers [PDF]
Journal of Genetic Engineering and BiotechnologyCancer burden has become a global concern, specifically with hormone-sensitive cancers (HSC). Among the various factors influencing the progress and treatment of cancers, the human microbiota plays a vital role.
Suvitha Anbarasu +3 more
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Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity [PDF]
mBioGuanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She +9 more
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Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region. [PDF]
Epilepsia, 2019 SummaryObjectiveTo characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype‐protein structure‐phenotype relationships.MethodsWe evaluated the phenotypes of 14 patients with GNAO1 variants, analyzed their variants for potential pathogenicity, and mapped them, along with those in the literature, on a three‐dimensional ...
Kelly M +23 more
europepmc +8 more sources
The Isolation of Guanosine Tetraphosphate from Commercially Available Preparations of Guanosine Triphosphate [PDF]
Journal of Biological Chemistry, 1965 Mahlon B. Hoagland, J.A.A. Gardner
openaire +3 more sources
Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression [PDF]
ACS Omega, 2020 Burge Ulukan +5 more
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Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus. [PDF]
J Diabetes Metab Disord, 2020 Ünüvar S +4 more
europepmc +3 more sources
Rho GTPases in Skeletal Muscle Development and Homeostasis
Cells, 2021 Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
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