Elevated levels of plasma phenylalanine in schizophrenia: a guanosine triphosphate cyclohydrolase-1 metabolic pathway abnormality? [PDF]
PLoS ONE, 2014 BACKGROUND: Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia.
Olaoluwa Okusaga +15 more
doaj +4 more sources
Rho GTPases in Skeletal Muscle Development and Homeostasis [PDF]
Cells, 2021 Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj +4 more sources
A Small Guanosine Triphosphate Binding Protein PagRabE1b Promotes Xylem Development in Poplar [PDF]
Frontiers in Plant Science, 2021 Rab GTPases are the subfamily of the small guanosine triphosphate (GTP)-binding proteins which participated in the regulation of various biological processes. Recent studies have found that plant Rabs play some specific functions.
Ying-Li Liu +8 more
doaj +2 more sources
Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells [PDF]
BiologyIntravenously transplanted mesenchymal stromal cells (MSCs) have been shown to interact with endothelial cells and to migrate to tissues. However, intracellular signals regulating MSC migration are still incompletely understood.
Melanie Giesen +4 more
doaj +2 more sources
Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region. [PDF]
Epilepsia, 2019 SummaryObjectiveTo characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype‐protein structure‐phenotype relationships.MethodsWe evaluated the phenotypes of 14 patients with GNAO1 variants, analyzed their variants for potential pathogenicity, and mapped them, along with those in the literature, on a three‐dimensional ...
Kelly M +23 more
europepmc +9 more sources
An Effector of Hemoglobin Structure: The Guanosine 3\u27, 5\u27-Triphosphate [PDF]
Croatica Chemica Acta, 2012 The effect of guanosine 3\u27, 5\u27-triphosphate (GTP) on the hemoglobin structure was studied by UV-visible, fluorescence and circular dichroism (CD) spectroscopies, and cyclic voltammetry. UV-visible absorption spectra showed an increase in absorbance
Ali Akbar Saboury +5 more
core +3 more sources
The Isolation of Guanosine Tetraphosphate from Commercially Available Preparations of Guanosine Triphosphate [PDF]
Journal of Biological Chemistry, 1965 Jared Gardner, Mahlon B. Hoagland
openalex +3 more sources
Neural Regeneration Research, 2021 Several studies have confirmed that microglia are involved in neuropathic pain. Inhibition of guanosine-5′-triphosphate cyclohydrolase 1 (GTPCH1) can reduce the inflammation of microglia.
Yan-Hu Liang +4 more
doaj +2 more sources
Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression [PDF]
ACS Omega, 2020 Burge Ulukan +5 more
doaj +2 more sources
Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus. [PDF]
J Diabetes Metab Disord, 2020 Ünüvar S +4 more
europepmc +3 more sources