Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region. [PDF]
Epilepsia, 2019 SummaryObjectiveTo characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype‐protein structure‐phenotype relationships.MethodsWe evaluated the phenotypes of 14 patients with GNAO1 variants, analyzed their variants for potential pathogenicity, and mapped them, along with those in the literature, on a three‐dimensional ...
Kelly M +23 more
europepmc +9 more sources
Elevated levels of plasma phenylalanine in schizophrenia: a guanosine triphosphate cyclohydrolase-1 metabolic pathway abnormality? [PDF]
PLoS ONE, 2014 BACKGROUND: Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia.
Olaoluwa Okusaga +15 more
doaj +4 more sources
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. [PDF]
J Clin Invest, 2021 MYC stimulates both metabolism and protein synthesis, but it is unknown how cells coordinate these complementary programs. Previous work reported that in a subset of small cell lung cancer (SCLC) cell lines, MYC activates guanosine triphosphate (GTP ...
Huang F +27 more
europepmc +2 more sources
A Small Guanosine Triphosphate Binding Protein PagRabE1b Promotes Xylem Development in Poplar [PDF]
Frontiers in Plant Science, 2021 Rab GTPases are the subfamily of the small guanosine triphosphate (GTP)-binding proteins which participated in the regulation of various biological processes. Recent studies have found that plant Rabs play some specific functions.
Ying-Li Liu +8 more
doaj +2 more sources
Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments. [PDF]
J Cell Biol, 2018 We used electron tomography to examine microtubules (MTs) growing from pure tubulin in vitro as well as two classes of MTs growing in cells from six species.
McIntosh JR +6 more
europepmc +2 more sources
Frontiers in Pharmacology, 2018 The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells.
Tiziana Pietrangelo +9 more
doaj +2 more sources
Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells [PDF]
BiologyIntravenously transplanted mesenchymal stromal cells (MSCs) have been shown to interact with endothelial cells and to migrate to tissues. However, intracellular signals regulating MSC migration are still incompletely understood.
Melanie Giesen +4 more
doaj +2 more sources
Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons [PDF]
Journal of Neuroscience, 1988 These experiments show that a synaptic response in brain, namely, the late inhibitory postsynaptic potential (IPSP) of hippocampal CA3 neurons in the rat hippocampal slice, was blocked by 2 compounds affecting guanosine triphosphate (GTP)-binding ...
R. H. Thalmann
openalex +2 more sources
In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers [PDF]
Journal of Genetic Engineering and BiotechnologyCancer burden has become a global concern, specifically with hormone-sensitive cancers (HSC). Among the various factors influencing the progress and treatment of cancers, the human microbiota plays a vital role.
Suvitha Anbarasu +3 more
doaj +2 more sources
The Isolation of Guanosine Tetraphosphate from Commercially Available Preparations of Guanosine Triphosphate [PDF]
Journal of Biological Chemistry, 1965 Jared Gardner, Mahlon B. Hoagland
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