Results 261 to 270 of about 73,799 (301)
Some of the next articles are maybe not open access.
On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins
Biochemistry, 1992The residue Gln61 is assumed to play a major role in the mechanism of ras p21, and mutations of this residue are often found in human tumors. Such mutations lead to a major reduction in the rate of GTP hydrolysis by the complex of ras p21 and the GTPase activating protein (GAP) and lock the protein in a growth-promoting state.
Ralf Langen +2 more
openaire +3 more sources
Adenosine Triphosphate and Guanosine Triphosphate Determinations in Intertidal Sediments
1979Measurements were made of the spatial distributions of adenosine triphosphate (ATP) on a variety of sandy beaches. Samples were collected during ebb flow and extracted in the field using cold sulfuric acid and ethylenediamine tetraacetate (EDTA); the neutralized extracts were immediately frozen for subsequent analyses.
openaire +2 more sources
Evidence for Guanosine Triphosphate—Binding Proteins in Trypanosoma cruzi
The American Journal of Tropical Medicine and Hygiene, 1994The transformation of the parasite Trypanosoma cruzi from the blood-borne trypomastigote to the intracellular amastigote constitutes a key clinical feature in the pathophysiology of Chagas' disease. That this transition occurs without change in the integrity of the plasma membrane of the parasite suggests the presence of biochemical structures, i.e ...
Huan Huang +5 more
openaire +3 more sources
The effect of guanosine 5′-triphosphate analogues on protein synthesis
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract Four GTP analogues, 6-mercaptoguanosine 5′-triphosphate (I), N2-methylguanosine 5′-triphosphate (II), N2-dimethylguanosine 5′-triphosphate (III) and 8-bromoguanosine 5′-triphosphate, (IV) were synthesized chemically and tested for their ability to replace GTP in the cell-free amino acid incorporation system of Escherichia coli.
Morio Ikehara +3 more
openaire +3 more sources
Analytical Chemistry
Guanosine triphosphate (GTP)-binding proteins function as molecular switches in cell signaling, playing critical roles in various biological pathways. Their dysregulation is associated with the causes and progression of many diseases. Systematic analysis of GTP-binding proteins would facilitate studies of related signaling pathways and drugs ...
Can Gao +8 more
openaire +2 more sources
Guanosine triphosphate (GTP)-binding proteins function as molecular switches in cell signaling, playing critical roles in various biological pathways. Their dysregulation is associated with the causes and progression of many diseases. Systematic analysis of GTP-binding proteins would facilitate studies of related signaling pathways and drugs ...
Can Gao +8 more
openaire +2 more sources
Biochemistry, 1986
Using highly purified calf brain tubulin bearing [8-14C]guanosine 5'-diphosphate (GDP) in the exchangeable nucleotide site and heat-treated microtubule-associated proteins (both components containing negligible amounts of nucleoside diphosphate kinase and nonspecific phosphatase activities), we have found that a significant proportion of exchangeable ...
Janendra K. Batra +2 more
openaire +3 more sources
Using highly purified calf brain tubulin bearing [8-14C]guanosine 5'-diphosphate (GDP) in the exchangeable nucleotide site and heat-treated microtubule-associated proteins (both components containing negligible amounts of nucleoside diphosphate kinase and nonspecific phosphatase activities), we have found that a significant proportion of exchangeable ...
Janendra K. Batra +2 more
openaire +3 more sources
Structural and Functional Relationships of Guanosine Triphosphate Binding Proteins
1988Information available at present documents the existence of three well-defined classes of guanine nucleotide binding proteins functioning as signal transducers: Gs and Gi which stimulate and inhibit adenylate cyclase, respectively, and transducin which transmits and amplifies the signal from light-activated rhodopsin to cGMP-dependent phosphodiesterase
Ernst J.M. Helmreich, Thomas Pfeuffer
openaire +3 more sources
Location of the Guanosine Triphosphate (GTP) Hydrolysis Site in Microtubulesa
Annals of the New York Academy of Sciences, 1986The rate for GTP hydrolysis remains approximately constant during microtubule assembly from microtubular protein. This indicates that GTP hydrolysis does not accompany tubulin-GTP subunit addition to microtubule ends. We suggest that GTP, within tubulin-GTP subunits that are incorporated into microtubules, is hydrolyzed predominantly at one or both ...
openaire +3 more sources
Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency
The Journal of Pediatrics, 1985C'est la recherche systematique des pteridines dans les urines qui a permis de suspecter le deficit en GTP-cyclohydrolase, 1ere etape de la synthese de la tetrahydrobiopterine (BH 4 ) chez un bebe hyperphenylalaninemique (HPA). Le deficit en BH 4 , variante rare de l'HPA, differe de la PKU classique par le caractere evolutif de l'atteinte neurologique ...
Marie-Madeleine Roger +6 more
openaire +3 more sources
Light-induced phosphorylation of rod outer segments by guanosine triphosphate
Biochemical and Biophysical Research Communications, 1975Abstract Significant GTP-dependent protein kinase activity is present in isolated photoreceptors of the retina. No transfer of the γ- 32 P group from GTP-γ- 32 P to ATP was detected. Although no stimulation of GTP-kinase activity by cyclic GMP or cyclic AMP was observed, exposure of dark-adapted photoreceptors to light resulted in a 46-fold increase ...
Gopal Krishna +2 more
openaire +3 more sources