Results 21 to 30 of about 84,847 (305)

Guanosine triphosphate cyclohydrolase activity in rat tissues [PDF]

Biochemical Journal, 1984
The GTP cyclohydrolase activity of rat tissues has been studied by means of the measurement of formic acid release and neopterin synthesis from GTP. After gel filtration of a 45%-satd.-(NH4)2SO4 fraction of liver homogenates, three enzyme fractions were separated and named A1, A2 and A3 according to the order of their elution.
Z, Bellahsene, J L, Dhondt, J P, Farriaux   +2 more
openaire   +2 more sources

Extracellular Guanosine 5′-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine

Frontiers in Pharmacology, 2018
The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells.
Tiziana Pietrangelo, Ester S. Di Filippo, Marcello Locatelli, Francesco Piacenza, Marco Farina, Eleonora Pavoni, Andrea Di Donato, Denise Innosa, Mauro Provinciali, Stefania Fulle   +9 more
doaj   +1 more source

Compatibility of Nucleobases Containing Pt(II) Complexes with Red Blood Cells for Possible Drug Delivery Applications

Molecules, 2023
The therapeutic advantages of some platinum complexes as major anticancer chemotherapeutic agents and of nucleoside analogue-based compounds as essential antiviral/antitumor drugs are widely recognized.
Federica De Castro, Erika Stefàno, Francesco Paolo Fanizzi, Riccardo Di Corato, Pasant Abdalla, Francesca Luchetti, Maria Gemma Nasoni, Rosaria Rinaldi, Mauro Magnani, Michele Benedetti, Antonella Antonelli   +10 more
doaj   +1 more source

A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts [PDF]

, 1988
A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes of pea (Pisum sativum L.) chloroplasts.
A.M. Edelman, A.R. Ashton, C. foyer, C. Schindler, C.V.C. Glover, D.J. Arnon, F.A. Ventimiglia, G.E. Lienhard, G.M. Hathaway, G.M. Hathaway, G.M. Hathaway, H. Erdmann, H. Hidaka, J. Joyard, J. Soll, J. Soll, J. Soll, J. Soll, J.F. Allen, J.F. Kuo, J.G. Chafouleas, K. Birkenhead, K. Cline, K. Keegstra, P. Bhalla, R. Ranjeva, R.A. Douce, R.J.H. Budde, S. Gowda, S. Murakami, S.J. Coughlan, T.F.J. Yan, U.K. Laemmli, W.A. Laing, Z.F. Lin   +34 more
core   +1 more source

The advantage of channeling nucleotides for very processive functions [version 2; referees: 3 approved]

F1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan   +6 more
doaj   +1 more source

Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography

Nature Communications, 2020
Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation
Nikita B. Gudimchuk, Evgeni V. Ulyanov, Eileen O’Toole, Cynthia L. Page, Dmitrii S. Vinogradov, Garry Morgan, Gabriella Li, Jeffrey K. Moore, Ewa Szczesna, Antonina Roll-Mecak, Fazoil I. Ataullakhanov, J. Richard McIntosh   +11 more
doaj   +1 more source

The advantage of channeling nucleotides for very processive functions [version 1; referees: 3 approved]

F1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan   +6 more
doaj   +1 more source

Protocol for structural and biochemical analyses of RhoA GTPase

STAR Protocols, 2021
Summary: Ras GTPases in complex with Guanosine triphosphate (GTP) or GTP analog exhibit dynamic equilibrium between two interconvertible conformations—an inactive state 1 and an active state 2.
Yuan Lin, Miki Watanabe-Chailland, Yi Zheng   +2 more
doaj   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika, Bozó, Beáta, Cinar, Resat, Dochnal, Roberta Beatrix, Fábián, Gabriella, Kicsi, Emese Gabriella, Kékesi, Orsolya, Murányi, Marianna, Mácsai, Mónika, Szabó, Gyula, Szűcs, Mária, Tóth, Géza, Zentai, András   +12 more
core   +3 more sources

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source