Results 21 to 30 of about 83,988 (248)
DNA sensor cGAS-mediated immune recognition
Protein & Cell, 2016 The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly ...
Pengyan Xia +4 more
doaj +1 more source
Protocol for structural and biochemical analyses of RhoA GTPase
STAR Protocols, 2021 Summary: Ras GTPases in complex with Guanosine triphosphate (GTP) or GTP analog exhibit dynamic equilibrium between two interconvertible conformations—an inactive state 1 and an active state 2.
Yuan Lin +2 more
doaj +1 more source
The T2238C human atrial natriuretic peptide molecular variant and the risk of cardiovascular diseases [PDF]
, 2018 Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene.
Bianchi, Franca +5 more
core +2 more sources
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
, 2002 Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Hörth, P. +5 more
core +1 more source
Gαs slow conformational transition upon GTP binding and a novel Gαs regulator
iScience, 2023 Summary: G proteins are major signaling partners for G protein-coupled receptors (GPCRs). Although stepwise structural changes during GPCR–G protein complex formation and guanosine diphosphate (GDP) release have been reported, no information is available
Donghoon Ahn +12 more
doaj +1 more source
Dynamics of Microtubule Growth and Catastrophe [PDF]
, 2007 We investigate a simple model of microtubule dynamics in which a microtubule evolves by: (i) attachment of guanosine triphosphate (GTP) to its end at rate lambda, (ii) GTP converting irreversibly to guanosine diphosphate (GDP) at rate 1, and (iii ...
Antal, T. +4 more
core +1 more source
Nonenzymatic Formation of Guanosine 3′ : 5′-Monophosphate from Guanosine Triphosphate
Journal of Biological Chemistry, 1974 Abstract We observed the nonenzymatic formation of guanosine 3' : 5'-monophosphate (cyclic GMP) from GTP. The reaction was dependent upon heat and was accelerated by divalent cations and creatine phosphate. The formation of cyclic GMP was greater with increased incubation time, temperature, GTP concentration, and pH. All of the divalent cations tested (
H, Kimura, F, Murad
openaire +2 more sources
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
core +2 more sources
Role of ARHGEF3 as a GEF and mTORC2 Regulator
Frontiers in Cell and Developmental Biology, 2022 Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq +5 more
doaj +1 more source