Results 51 to 60 of about 177,246 (350)

Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine

Journal of Ginseng Research, 2015
Background: Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract.
Noo Ri Hong, Hyun Soo Park, Tae Seok Ahn, Hyun Jung Kim, Ki-Tae Ha, Byung Joo Kim   +5 more
doaj   +1 more source

Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]

, 2015
The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin, Lee, Kunwoo, Lingampalli, Nithya, Murthy, Niren, Tang, Richard, Yu, Pengzhi   +5 more
core   +3 more sources

Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years

Clinical Interventions in Aging, 2023
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B, Kusy K, Slominska EM, Ciekot-Sołtysiak M, Zieliński J   +4 more
doaj  

The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions

Biochemistry and Biophysics Reports, 2020
Rab proteins, a family of small guanosine triphosphatases, play key roles in intracellular membrane trafficking and the regulation of various cellular processes.
Takuya Murata, Yuka Unno, Mitsunori Fukuda, Naoko Utsunomiya-Tate   +3 more
doaj   +1 more source

Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Sirtuin 5 (SIRT5), a mitochondrial NAD+‐dependent deacylase, regulates fundamental cellular pathways, including energy substrate metabolism. The current study is designed to better elucidate the role of SIRT5 in the development of heart failure (HF). Methods Mice with cardiomyocyte‐specific deletion (cSirt5−/−) or overexpression (cSirt5‐Tg)
Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.   +26 more
europepmc   +2 more sources

Substrate-Induced Self-Assembly of Cooperative Catalysts [PDF]

, 2018
Dissipative self-assembly processes in Nature rely on chemical fuels that activate proteins for assembly through the formation of a noncovalent complex.
Alberts, Ashkenasy, Boekhoven, Boekhoven, Bowne-Anderson, Caplow, Che, Chen, Cheng, Colomer, Dambenieks, Datta, David-Pfeuty, De, Del Grosso, Della Sala, della Sala, Dhiman, Dhiman, England, Fanlo-Virgós, Gruber, Grzybowski, Hao, Hess, Hoffmann, Kariyawasam, Kassem, Köstereli, Li, Maiti, Manea, Mattia, Merindol, Mishra, Pezzato, Pezzato, Ragazzon, Sasaki, Sawczyk, Sorrenti, Tena-Solsona, Tena-Solsona, van Ravensteijn, van Rossum, Wang, Wei, Wood, Zana, Zaupa   +49 more
core   +1 more source

Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels upon T Cell Activation

Journal of Biological Chemistry, 2011
Tetrahydrobiopterin (BH4) is an essential co-factor for the nitric-oxide (NO) synthases, and in its absence these enzymes produce superoxide (O2̇̄) rather than NO.
Wei Chen, Li Li, Torben Brod, O. Saeed, Salim R. Thabet, T. Jansen, S. Dikalov, C. Weyand, J. Goronzy, D. Harrison   +9 more
semanticscholar   +1 more source

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

Bioorganic & Medicinal Chemistry, 2012
Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 2'-SeCH(3)-uridine and 2'-SeCH(3)-cytidine derivatized RNAs for applications in RNA crystallography, using the corresponding nucleoside triphosphates and distinct
Santner, Tobias, Micura, Ronald, Siegmund, Vanessa, Marx, Andreas   +3 more
openaire   +4 more sources

Glucocorticoids and the regulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in the rat [PDF]

Biochemical Journal, 1975
The effect glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP)(EC4.1.1.32) in rat liver and kidney in vivo was studied immunochemically. The glucocorticoid analogue triamcinolone (9α-fluoro-11β, 21-dihydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione) increased the synthesis rate of the kidney enzyme ...
Lea Reshef, O Meyuhas, J M Gunn, Richard W. Hanson, F.J. Ballard   +4 more
openaire   +3 more sources

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source