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Soluble guanylate cyclase: the forgotten sibling
Trends in Pharmacological Sciences, 1997Despite widespread distribution in most mammalian cells, the role of soluble guanylate cyclase has, until recently, been poorly defined, especially when compared with its more illustrious sibling, adenylate cyclase. In this review Adrian Hobbs outlines some of the reasons why the soluble guanylate cyclase-cGMP pathway has remained outside the ...
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1989
Following the discovery of adenylate cyclase (Sutherland et al. 1962), the enzyme guanylate cyclase was identified (Hardman and Sutherland 1969; Schultz et al. 1969; White and Aurbach 1969). By the time of its discovery, the “second messenger hypothesis” was well in place and it was initially felt that the mechanisms by which guanylate cyclase were ...
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Following the discovery of adenylate cyclase (Sutherland et al. 1962), the enzyme guanylate cyclase was identified (Hardman and Sutherland 1969; Schultz et al. 1969; White and Aurbach 1969). By the time of its discovery, the “second messenger hypothesis” was well in place and it was initially felt that the mechanisms by which guanylate cyclase were ...
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Subcellular localization of guanylate cyclase
Life Sciences, 1975H, Kimura, F, Murad
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