Results 191 to 200 of about 39,412 (236)
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Soluble guanylate cyclases in the retina
Molecular and Cellular Biochemistry, 2002Soluble guanylate cyclase catalyzes the formation of cyclic GMP using GTP as substrate. It is now well established that soluble guanylate cyclase is highly activated by nitric oxide, and that many of the effects of nitric oxide on various cells and tissues are mediated through increased production of cyclic GMP.
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Adenylate and Guanylate Cyclases in Tetrahymena
1996Cyclic nucleotides, such as cyclic AMP (cAMP) and cyclic GMP (cGMP), are of fundamental importance in regulating the many physiologic processes in a wide variety of living cells, acting as messengers interacting between receptor sites on the cell membrane and intracellular activity.
S, Umeki, Y, Nozawa
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Inhibition of Soluble Guanylate Cyclase by ODQ
Biochemistry, 2000The heme in soluble guanylate cyclases (sGC) as isolated is ferrous, high-spin, and 5-coordinate. [1H-[1,2,4]oxadiazolo-[4, 3-a]quinoxalin-1-one] (ODQ) has been used extensively as a specific inhibitor for sGC and as a diagnostic tool for identifying a role for sGC in signal transduction events.
Y, Zhao +6 more
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Structure and Regulation of Soluble Guanylate Cyclase
Annual Review of Biochemistry, 2012Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it functions as the primary activator of soluble guanylate cyclase (sGC). NO is synthesized from l-arginine and oxygen (O2) by the enzyme nitric oxide synthase (NOS). Once produced,
Emily R, Derbyshire, Michael A, Marletta
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Guanylate Cyclase Receptor Family
1990The plasma membrane forms of guanylate cyclase contain a highly conserved catalytic domain, which is also conserved in the soluble form of the enzyme and in mammalian adenylate cyclase. A protein kinase-like domain lies to the amino-terminal side of the catalytic domain and appears to be required for signaling via cGMP; it might also signal, itself ...
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Activation of kidney guanylate cyclase by cobalt
Archives of Biochemistry and Biophysics, 1978Abstract Guanylate cyclase activity and cyclic nucleotide content were studied in individual slices from guinea pig kidneys. Basal guanylate cyclase activity, assayed in homogenates or in particulate fractions (100,000g × 1 h), and the tissue content of cGMP and cAMP were greater in the inner than in the outer (entirely cortical) slices. The fraction
S C, Tsai, V C, Manganiello, M, Vaughan
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A simple and sensitive assay for guanylate cyclase
Analytical Biochemistry, 1976A simple and highly sensitive method for the assay of guanylate cyclase has been developed which is capable of measuring cyclic 3′–5′ GMP (cGMP) formation in picomole quantities. In the method, 10–100 μg of enzyme protein is incubated with 1m m [α-32P]GTP, 40 m m Tris-HCl buffer (pH 7.4), 3.3 m m Mn2+, 10 m m theophylline, and 1 m m cGMP.
N, Krishnan, G, Krishna
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Nicotine decreases guanylate cyclase activity
Bulletin of Environmental Contamination and Toxicology, 1978The cyclic nucleotide, guanosine 3',5'-monophosphate (cyclic GMP) appears to serve a critical role in normal cell growth, DNA synthesis, and carcinogenesis (GOLDBERG et al. 1977). Tobacco smoke and hydrazine, a carcinogen which occurs in tobacco and tobacco smoke, have been shown to stimulate guanylate cyclase [E.C.
D L, Vesely, G S, Levey
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Emerging Therapeutic Targets, 2000
Soluble guanylate cyclase (sGC) is a heterodimeric haemoprotein, which represents the intracellular receptor for the ubiquitous biological messenger nitric oxide (NO). Activation of the enzyme facilitates conversion of GTP to the intracellular second messenger cGMP, and it is this molecule which mediates the majority of biological actions attributed to
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Soluble guanylate cyclase (sGC) is a heterodimeric haemoprotein, which represents the intracellular receptor for the ubiquitous biological messenger nitric oxide (NO). Activation of the enzyme facilitates conversion of GTP to the intracellular second messenger cGMP, and it is this molecule which mediates the majority of biological actions attributed to
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Diabetes Research and Clinical Practice
Diabetic kidney disease (DKD) is a word-wide problem. In patients with diabetes mellitus (DM), DKD occurs in up to 40% of patients and is the most common cause of chronic kidney disease (CKD) in diabetic patients. Despite various reno-protective agents, DKD still progresses in the majority of patients necessitating further novel therapeutic options ...
Baris Afsar +2 more
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Diabetic kidney disease (DKD) is a word-wide problem. In patients with diabetes mellitus (DM), DKD occurs in up to 40% of patients and is the most common cause of chronic kidney disease (CKD) in diabetic patients. Despite various reno-protective agents, DKD still progresses in the majority of patients necessitating further novel therapeutic options ...
Baris Afsar +2 more
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