A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide. [PDF]
PLoS ONE, 2015 Tissue injury and infection trigger innate immune responses. However, dysregulation may result in chronic inflammation and is commonly treated with corticosteroids and non-steroidal anti-inflammatory drugs. Unfortunately, long-term administration of both
Christine Wittmann +6 more
doaj +1 more source
Regulation of nitric oxide signaling by formation of a distal receptor-ligand complex. [PDF]
, 2017 The binding of nitric oxide (NO) to the heme cofactor of heme-nitric oxide/oxygen binding (H-NOX) proteins can lead to the dissociation of the heme-ligating histidine residue and yield a five-coordinate nitrosyl complex, an important step for NO ...
Britt, R David +5 more
core +1 more source
Vericiguat: A New Hope for Heart Failure Patients
Cardiovascular Therapeutics, 2022 Heart failure with reduced ejection fraction (HFrEF) is the inability of the heart to adequately contract or eject blood. This heart is unable to produce adequate cardiac output to perfuse vital tissues.
Raquel Chiles, Rami A. Al-Horani
doaj +1 more source
Recoverin Regulates Light-dependent Phosphodiesterase Activity in Retinal Rods [PDF]
, 2004 The Ca2+-binding protein recoverin may regulate visual transduction in retinal rods and cones, but its functional role and mechanism of action remain controversial.
Baylor, D. A. +6 more
core +5 more sources
Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm [PDF]
, 2020 Intracellular calcium ([Ca2+]i) is a basic and ubiquitous cellular signal controlling a wide variety of biological processes. A remarkable example is the steering of sea urchin spermatozoa towards the conspecific egg by a spatially and temporally ...
Carneiro, Jorge +6 more
core +2 more sources
What can we learn from SOCRATES: more questions than answers? [PDF]
, 2017 This editorial refers to ‘Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) Study’, by B ...
Cleland, John G.F., Mueller, Christian
core +1 more source
Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations
Frontiers in Molecular Neuroscience, 2014 Membrane bound guanylate cyclases are expressed in rod and cone cells of the vertebrate retina and mutations in several domains of rod outer segment guanylate cyclase 1 (ROS-GC1 encoded by the gene GUCY2D) correlate with different forms of retinal ...
Patrick eZägel, Karl-Wilhelm eKoch
doaj +1 more source
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
Nature Communications, 2021 Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent ...
Andrea de la Fuente-Alonso +20 more
doaj +1 more source
Guanylyl cyclase activation reverses resistive breathing–induced lung injury and inflammation [PDF]
, 2015 Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway is down-regulated in chronic and acute animal models of RB, such as ...
Brouckaert, Peter +15 more
core +2 more sources
Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. [PDF]
, 2013 BACKGROUND: Riociguat, a member of a new class of compounds (soluble guanylate cyclase stimulators), has been shown in previous clinical studies to be beneficial in the treatment of chronic thromboembolic pulmonary hypertension. METHODS: In this phase 3,
CHEST-1 Study Group, +13 more
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