Results 181 to 190 of about 4,450,920 (398)

Guide RNAs with 5′ Caps and Novel Box C/D snoRNA-like Domains for Modification of snRNAs in Metazoa [PDF]

, 2004
Kazimierz T. Tycowski, Alar Aab, Joan A. Steitz   +2 more
openalex   +1 more source

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

Nature Biotechnology, 2013
Jian-Feng Li, J. Norville, John D Aach, M. McCormack, Dandan Zhang, Jenifer Bush, G. Church, J. Sheen   +7 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

Nature, 2016
Alexandra East-Seletsky, M. O’Connell, Spencer C. Knight, D. Burstein, J. Cate, R. Tjian, J. Doudna   +6 more
semanticscholar   +1 more source

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]

, 2018
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan, Li, Lili, Tang, Lixu, Wang, Yan, Wang, Yibin, Wang, Zhihua, Xie, Yinping, Yu, Ling, Yu, Pengcheng, Zheng, Di   +9 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Restoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing

Biomolecules
RNA editing is a significant mechanism underlying genetic variation and protein molecule alteration; C-to-U RNA editing, specifically, is important in the regulation of mammalian genetic diversity.
Sonali Bhakta, Hiroko Kodama, Masakazu Mimaki, Toshifumi Tsukahara   +3 more
doaj   +1 more source

SnapShot: CRISPR-RNA-Guided Adaptive Immune Systems

, 2015
Joshua Carter, Blake Wiedenheft
openalex   +1 more source

License to cut: Smart RNA guides for conditional control of CRISPR-Cas9 [PDF]

, 2022
Alexandre Baccouche, Arman Adel, Nozomu Yachie, Teruo Fujii, Anthony J. Genot   +4 more
openalex   +1 more source